4-(3-Thienyl)-2-pyrimidinamine (CAS 206564-03-6)
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(5Z)-7-Oxozeaenol also known as antibiotic LL Z1640-2 is a signal-specific inhibitor of the JNK/p38 pathways that may act to inhibit anisomycin-induced but not TNF-induced JNK/p38 activation. Shown to inhibit HgCl2 and CdCl2 MAPKs activation, while not affecting total protein level, in CCRF-CEM and NIH3T3 cells, respectively. Like other members of the resorcylic acid lactone (RAL) family,(5Z)-7-Oxozeaenol targets the ATP-binding pocket of kinases. Unlike other RALs, irreversibly inhibits TAK1. This cis-enone resorcylic acid lactone was first reported in 1978 and later rediscovered as an irreversible and highly selective TAK1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-(3-Thienyl)-2-pyrimidinamine, 1 mg | sc-314392 | 1 mg | $70.00 | |||
4-(3-Thienyl)-2-pyrimidinamine, 100 mg | sc-314392A | 100 mg | $80.00 |