3-(tert-Butylamino)propanamide
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Pifithrin-α hydrobromide is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. It enhances cell survival after genotoxic stress such as UV irradiation and treatment with cytotoxic compounds including doxorubicin (sc-280681), etopoxide, paclitaxel, and cytosine-β-D-arabinofuranoside. Additionally, Pifithrin-α is an aryl hydrocarbon receptor (AHR) agonist, which leads to the upregulation of AHR target gene CYP1A1 (EC50 = 1.1 µM). Uses of pifithrin-α hydrobromide extend to the study of cellular resilience and adaptability in response to environmental stresses. Researchers can study how modulation of transcription factor activities can impact cellular decision-making processes, including survival, adaptation, and response to external signals.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-(tert-Butylamino)propanamide, 500 mg | sc-310375 | 500 mg | $284.00 |