3-O-Acetyl-beta-boswellic acidA non-competitive 5-lipoxygenase and topoisomerase I and IIa

3-O-Acetyl-β-boswellic acid (CAS 5968-70-7)

3-O-Acetyl-β-boswellic acid | CAS 5968-70-7 is rated 5.0 out of 5 by 1.
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Synonym: A-beta-BA
Application: A non-competitive 5-lipoxygenase and topoisomerase I and IIa
CAS Number: 5968-70-7
Purity: ≥95%
Molecular Weight: 498.74
Molecular Formula: C32H50O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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3-O-Acetyl-β-boswellic acid shows antitumor and anti-inflammatory activities. 3-O-Acetyl-β-boswellic acid is a potent non-redox, non-competitive 5-LO (5-lipoxygenase) and Topo I (topoisomerase I) and Topo II (topoisomerase II) inhibitor leading to apoptosis and is 10-100 times more potent than natural boswellic acid. 3-O-Acetyl-β-boswellic acid is an inhibitor of Topo II α.


References

Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers: V. Sterk, et al.; Planta Med. 70, 1155 (2004) Effects of Boswellia serrata in mouse models of chemically induced colitis: P.R. Kiela, et al.; Am. J. Physiol. Gastrointest. Liver. Physiol. 288, G798 (2005) Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC- 3 prostate cancer cells in vitro and in vivo: T. Syrovets, et al.; J. Biol. Chem. 280, 6170 (2005) Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid: D. Poeckel, et al.; Br. J. Pharmacol. 146, 514 (2005) Boswellic acids: biological actions and molecular targets: D. Poeckel & O. Werz; Curr. Med. Chem. 13, 3359 (2006)

Physical State :
Solid
Derived From :
Boswellia sp.
Solubility :
Soluble in acetone, DMF, DMSO, dichloromethane, 100% ethanol, methanol, and water (sparingly).
Storage :
Store at -20° C
Melting Point :
230.22° C (Predicted)
Boiling Point :
566.75° C at 760 mmHg (Predicted)
Density :
1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
HL-60: IC50 = 10 µM (human); HeLa: IC50 = 22 µM (human)
pK Values :
pKa: 4.32 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11386458
MDL Number :
MFCD03788773
SMILES :
C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@H]([C@]5(C)C(=O)O)OC(=O)C)C)C)[C@@H]2[C@H]1C)C)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Various publications cite 3 Various publications cite 3-O-Acetyl- -boswellic acid as a potent non-redox, non-competitive 5-LO (5-lipoxygenase) and Topo I (topoisomerase I) and Topo II (topoisomerase II) inhibitor. -SCBT Publication Review
Date published: 2015-02-07
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