3-Methyl-5-AIQ hydrochloride is a strong inhibitor of poly(ADP-ribose) polymerase-1 in vitro. Exhibits outstanding therapeutic benefits in models of myocardial infarction, ischaemia-reperfusion of the liver and kidney, heart transplantation and acute lung inflammation.
Synthesis and PARP-1 inhibitory activity of 3-substituted analogues of the potent water-soluble PARP inihbitor 5-aminoisoquinolin-1-one (5-AIQ): E. C. Y. Woon, et al.; Bioorg. Med. Chem. (submitted), (2006)
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