3-Bromobenzotrifluoride (CAS 401-78-5)
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3-Bromobenzotrifluoride appears as a colorless to pale yellow liquid. While it mixes well with organic solvents such as dichloromethane, ethyl acetate, and acetone, it doesn′t dissolve in water. This compound serves as a chemical reagent, notably in the creation of aryl halides. One application involves its use in cross-coupling reactions where an aryl bromide interacts with an organopalladium complex, producing an aryl triflate. Due to its thermal stability, 3-Bromobenzotrifluoride is a preferred choice for synthesis processes. Its distinct properties make it versatile for several roles, from a reagent in organic synthesis to a solvent in chromatography, a probe in nuclear magnetic resonance spectroscopy, and even a derivatizing agent in mass spectrometry. Additionally, it can be employed in assessing the biological effects of various substances, including pesticides.
3-Bromobenzotrifluoride (CAS 401-78-5) References
- Synthesis of primary aromatic amides by aminocarbonylation of aryl halides using formamide as an ammonia synthon. | Schnyder, A., et al. 2001. J Org Chem. 66: 4311-5. PMID: 11397169
- Synthesis of unsymmetrical aroyl acyl imides by aminocarbonylation of aryl bromides. | Schnyder, A. and Indolese, AF. 2002. J Org Chem. 67: 594-7. PMID: 11798337
- Convenient processes for the synthesis of aromatic ketones from aryl bromides and carboxylic anhydrides using a cobalt catalysis. | Kazmierski, I., et al. 2004. J Org Chem. 69: 936-42. PMID: 14750825
- Palladium-catalyzed synthesis of cyclopentane-fused benzocyclobutenes via tandem directed carbopalladation/C-H bond functionalization. | Bertrand, MB. and Wolfe, JP. 2007. Org Lett. 9: 3073-5. PMID: 17616201
- Stereoselective synthesis of isoxazolidines through Pd-catalyzed carboetherification of N-butenylhydroxylamines. | Hay, MB. and Wolfe, JP. 2007. Angew Chem Int Ed Engl. 46: 6492-4. PMID: 17657749
- Rational catalysis design on the basis of mechanistic understanding: highly efficient Pd-catalyzed cyanation of aryl bromides with NaCN in recyclable solvents. | Ushkov, AV. and Grushin, VV. 2011. J Am Chem Soc. 133: 10999-1005. PMID: 21699208
- Sensitive near-infrared fluorescent probes for thiols based on Se-N bond cleavage: imaging in living cells and tissues. | Wang, R., et al. 2012. Chemistry. 18: 11343-9. PMID: 22829328
- Palladium-catalyzed α-arylation of benzylic phosphine oxides. | Montel, S., et al. 2014. Org Lett. 16: 130-3. PMID: 24295336
- Room-temperature palladium-catalyzed direct 2-arylation of benzoxazoles with aryl and heteroaryl bromides. | Gao, F., et al. 2014. Chem Commun (Camb). 50: 10661-4. PMID: 25078988
- Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions. | Huck, L., et al. 2017. Org Lett. 19: 3747-3750. PMID: 28657761
- One-Pot Iridium Catalyzed C-H Borylation/Sonogashira Cross-Coupling: Access to Borylated Aryl Alkynes. | Chotana, GA., et al. 2020. Molecules. 25: PMID: 32290238
- Optofluidic detection setup for multi-parametric analysis of microbiological samples in droplets. | Hengoju, S., et al. 2020. Biomicrofluidics. 14: 024109. PMID: 32547676
- Base-catalyzed aryl halide isomerization enables the 4-selective substitution of 3-bromopyridines. | Puleo, TR. and Bandar, JS. 2020. Chem Sci. 11: 10517-10522. PMID: 34094310
- A microscopic test for rapid detection of antibodies against Mycoplasma pneumoniae. | Bredt, W. 1969. Experientia. 25: 436-7. PMID: 4895038
- The preparation and antibacterial activity of 3,3'-bis(trifluoromethyl) tetranitrodiphenylamine. | Fritsch, AJ., et al. 1969. Experientia. 25: 437-8. PMID: 4979094
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Bromobenzotrifluoride, 500 g | sc-280353 | 500 g | $86.00 |