3-Bromo-7-nitroindazoleA selective inhibitor of NOS1 and NOS3

3-Bromo-7-nitroindazole (CAS 74209-34-0)

3-Bromo-7-nitroindazole | CAS 74209-34-0 is rated 5.0 out of 5 by 1.
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Synonym: 3-Bromo-7-nitro-1H-indazole
Application: A selective inhibitor of NOS1 and NOS3
CAS Number: 74209-34-0
Molecular Weight: 242.03
Molecular Formula: C7H4BrN3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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3-Bromo-7-nitroindazole is a 7-nitro indazole derivative that inhibits bovine NOS3 and rat NOS1 enzyme activity. This compound was also reported to provide significant neuroprotection against ischaemia-induced brain damage in rat models. Experiments suggest that 3-Bromo-7-nitroindazole displays the capacity to prevent effects of MCPG, a metabotropic receptor antagonist. Metabotropic receptors decrease synaptic transmission in murine models.


References

1. Bland-Ward, P.A., et al. 1995. Life Sci. 57: PL131-PL135. PMID: 7544863
2. O'Neill, M.J., et al. 1997. Brain Res. 760: 170-178. PMID: 9237532
3. Wada, K., et al. 1998. J. Neurosurg. 89: 807-818. PMID: 9817419

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mg/ml), DMF (~20 mg/ml), ethanol (~20 mg/ml), PBS (pH 7.2) (~50 µg/ml), 50:50 solution of DMSO:water (1 mg/ml), methanol, water containing 10% DMSO, dichloromethane, ethyl acetate, and water (< 50 µg/ml) at 25° C.
Storage :
Store at -20° C
Melting Point :
153.23° C (Predicted)
Boiling Point :
~437.3° C at 760 mmHg (Predicted)
Density :
~2.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.76
IC50 :
nNOS: IC50 = 0.17 µM (rat); eNOS: IC50 = 0.86 µM (bovine); iNOS: IC50 = 0.29 µM (rat); LPS and gamma-IFN-stimulated nitrite accumulation : IC50 = 80 µM (mouse RAW 264.7 cells )
pK Values :
pKa: 7.85
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
1649
MDL Number :
MFCD00159910
SMILES :
C1=CC2=C(NN=C2C(=C1)[N+](=O)[O-])Br

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Gocmez Gocmez, SS. et al. (PubMed 25636602) used the selective neuronal nitric oxide synthase inhibitor 3-Bromo-7-nitroindazole to investigate its effects on spatial learning and memory in rats. -SCBT Publication Review
Date published: 2015-05-18
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