3,4-Dihydroxyphenyl EthanolCAS: 10597-60-1
MF: C8H10O3
MW: 154.16
A phenolic antioxidant inhibitor of 5- and 12-lipoxygenase.

3,4-Dihydroxyphenyl Ethanol (CAS 10597-60-1)

3,4-Dihydroxyphenyl Ethanol | CAS 10597-60-1 is rated 5.0 out of 5 by 1.
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Synonym: 2-(3,4-Dihydroxyphenyl)ethyl alcohol; 3-Hydroxytyrosol
Application: A phenolic antioxidant inhibitor of 5- and 12-lipoxygenase
CAS Number: 10597-60-1
Purity: ≥98%
Molecular Weight: 154.16
Molecular Formula: C8H10O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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3,4-Dihydroxyphenyl Ethanol is a phenolic compound present in olive oil, described to inhibit 5-lipoxygenase (5-LO) and 12-lipoxygenase activity (12-LO). 3,4-Dihydroxyphenyl Ethanol is demonstrated to inhibit 5-LO (IC50 = 13 μM) in rat polymorphonuclear leukocytes and 12-LO (IC50 = 4.2 μM) in rat platelets. Oxidative damage induced by H2O2 or a xanthine/xanthine oxidase system on human Caco-2 cells was strongly suppressed by exposure to 3,4-Dihydroxyphenyl Ethanol, indicating reactive oxygen species scavenging activity of the compound. 3,4-Dihydroxyphenyl Ethanol is demonstrated to increase cytosolic Ca2+ levels in human lymphomonocytes. 3,4-Dihydroxyphenyl Ethanol is also described to induce growth arrest and apoptosis in human colon carcinoma HT-29 cells through activation of the serine/threonine protein phosphatase 2A.


References

1. Kohyama, N., et al. 1997. Biosci. Biotechnol. Biochem. 61: 347-350. PMID: 9058975
2. Manna, C., et al. 1997. J. Nutr. 127: 286-292. PMID: 9039829
3. Palmerini, C.A., et al. 2005. J. Nutr. Biochem. 16: 109-113. PMID: 15681170
4. Guichard, C., et al. 2006. Carcinogenesis. 27: 1812-1827. PMID: 16524888

Formulation :
A solution in ethanol
Physical State :
Liquid
Solubility :
Soluble in water (50mg/ml)
Storage :
Store at -20° C
Boiling Point :
78° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
82755
SMILES :
C1=CC(=C(C=C1CCO)O)O

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3,4-Dihydroxyphenyl Ethanol  Product Citations

See how others have used 3,4-Dihydroxyphenyl Ethanol. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 7514253  Grignaffini, P. et al. 1994. Lancet. 343: 1296-1297.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Grignaffini P; et al Grignaffini P; et al. (PubMed ID: 7514253) determined that 3,4-Dihydroxyphenyl Ethanol protects low-density lipoprotein from oxidation. -SCBT Publication Review
Date published: 2015-07-10
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