3-(4-Chlorophenyl)quinoxaline-5-carboxamideAn inhibitor of PARP with 5-fold selectivity for PARP-2 over PARP-1

3-(4-Chlorophenyl)quinoxaline-5-carboxamide

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Application: An inhibitor of PARP with 5-fold selectivity for PARP-2 over PARP-1
Molecular Weight: 283.7
Molecular Formula: C15H10ClN3O
* Refer to Certificate of Analysis for lot specific data (including water content).
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3-(4-Chlorophenyl)quinoxaline-5-carboxamide is a strong quinoxaline-based PARP inhibitor with a 5-fold selectivity towards PARP-2 over PARP-1.


References

Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors: A. Iwashita, et al.; FEBS Lett. 579, 1389 (2005) Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling: J. Ishida, et al.; Bioorg. Med. Chem. 14, 1378 (2006)

Physical State :
Solid
Solubility :
Soluble in DMSO
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
657038
SMILES :
C1=CC(=C2C(=C1)N=CC(=N2)C3=CC=C(C=C3)Cl)C(=O)N

Download SDS (MSDS)

Certificate of Analysis

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