3-(4-Chlorophenyl)quinoxaline-5-carboxamide is a strong quinoxaline-based PARP inhibitor with a 5-fold selectivity towards PARP-2 over PARP-1.
Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors: A. Iwashita, et al.; FEBS Lett. 579, 1389 (2005) Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling: J. Ishida, et al.; Bioorg. Med. Chem. 14, 1378 (2006)
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