3,3prime-DiindolylmethaneAn antineoplastic agent that activates Chk 2 and cytochrome p450

3,3′-Diindolylmethane (CAS 1968-05-4)

3,3′-Diindolylmethane | CAS 1968-05-4 is rated 5.0 out of 5 by 1.
  • y_2019, m_11, d_14, h_22
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.2
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_204624, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 122ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: DIM; Plant Indole; 3,3'-Methylenediindole
Application: An antineoplastic agent that activates Chk 2 and cytochrome p450
CAS Number: 1968-05-4
Purity: ≥98%
Molecular Weight: 246.31
Molecular Formula: C17H14N2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

3,3'-Diindolylmethane is an anticancer and antineoplastic agent. 3,3'-Diindolylmethane induces apoptosis in human cancer cells. 3,3'-Diindolylmethane is also an activator of CYP (cytochrome P450) and Chk2 (checkpoint kinase 2) as well as a partial agonist of aryl hydrocarbon receptor (Ah Receptor). The compound is a dimer of indole-3-carbinol (sc-202662).


References

Oligomerization of indole-3-carbinol in aqueous acid: K.R. Grose & L.F. Bjeldanes; Chem. Res. Toxicol. 5, 188 (1992) The anticarcinogen 3,3'-diindolylmethane is an inhibitor of cytochrome P-450: D.M. Stresser, et al.; J. Biochem. Toxicol. 10, 191 (1995) 3,3'-Diindolylmethane induces apoptosis in human cancer cells: X. Ge, et al.; BBRC 228, 153 (1996) Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells: I. Chen, et al.; Biochem. Pharmacol. 51, 1069 (1996) 3,3-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices: B.G. Lake, et al.; Xenobiotica 28, 803 (1998) Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor: E.V. Hestermann & M. Brown; Mol. Cell. Biol. 23, 7920 (2003) Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines: L. Mulvey, et al.; Mol. Med. 13, 69 (2007) 3,3'-Diindolylmethane stimulates murine immune function in vitro and in vivo: L. Xue, et al.; J. Nutr. Biochem. 19, 336 (2008) 3,3-diindolylmethane reduces levels of HIF-1alpha and HIF-1 activity in hypoxic cultured human cancer cells: J.E. Riby, et al.; Biochem. Pharmacol. 75, 1858 (2008) Indole-3-carbinol as a chemopreventive and anti-cancer agent: J.R. Weng, et al.; Cancer Lett. 262, 153 (2008)

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (200 mg/ml), ethanol (50 mM), chloroform, and methanol. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
167° C
Boiling Point :
~504.2° C at 760 mmHg (Predicted)
Density :
~1.30 g/cm3 (Predicted)
Refractive Index :
n20D 1.77 (Predicted)
IC50 :
Leishmania donovani: IC50 = 1.25 µM; MCF7: IC50 = 5.5 µM (human); MDA-MB-231: IC50 = 10 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NM0332000
PubChem CID :
3071
MDL Number :
MFCD00195766
Beilstein Registry :
223072
SMILES :
C1=CC=C2C(=C1)C(=CN2)CC3=CNC4=CC=CC=C43

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

3,3prime-Diindolylmethane  Product Citations

See how others have used 3,3prime-Diindolylmethane. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27430727  Li, H.|Zhao, P.|Xu, Q.|Shan, S.|Hu, C.|Qiu, Z.|Xu, X.| et al. 2016. Sci Rep. 6: 29878.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 92ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Ye Ye, Y. et al. (PubMed 26137077) reported that 3,3'-Diindolylmethane potentiates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of gastric cancer cells. -SCBT Publication Review
Date published: 2015-03-04
  • y_2019, m_11, d_14, h_22
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.2
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_204624, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 32ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.