3,3'-Diindolylmethane is an anticancer and antineoplastic agent. 3,3'-Diindolylmethane induces apoptosis in human cancer cells. 3,3'-Diindolylmethane is also an activator of CYP (cytochrome P450) and Chk2 (checkpoint kinase 2) as well as a partial agonist of aryl hydrocarbon receptor (Ah Receptor). The compound is a dimer of indole-3-carbinol (sc-202662).
Oligomerization of indole-3-carbinol in aqueous acid: K.R. Grose & L.F. Bjeldanes; Chem. Res. Toxicol. 5, 188 (1992) The anticarcinogen 3,3'-diindolylmethane is an inhibitor of cytochrome P-450: D.M. Stresser, et al.; J. Biochem. Toxicol. 10, 191 (1995) 3,3'-Diindolylmethane induces apoptosis in human cancer cells: X. Ge, et al.; BBRC 228, 153 (1996) Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells: I. Chen, et al.; Biochem. Pharmacol. 51, 1069 (1996) 3,3-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices: B.G. Lake, et al.; Xenobiotica 28, 803 (1998) Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor: E.V. Hestermann & M. Brown; Mol. Cell. Biol. 23, 7920 (2003) Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines: L. Mulvey, et al.; Mol. Med. 13, 69 (2007) 3,3'-Diindolylmethane stimulates murine immune function in vitro and in vivo: L. Xue, et al.; J. Nutr. Biochem. 19, 336 (2008) 3,3-diindolylmethane reduces levels of HIF-1alpha and HIF-1 activity in hypoxic cultured human cancer cells: J.E. Riby, et al.; Biochem. Pharmacol. 75, 1858 (2008) Indole-3-carbinol as a chemopreventive and anti-cancer agent: J.R. Weng, et al.; Cancer Lett. 262, 153 (2008)
See how others have used 3,3prime-Diindolylmethane. Click on the entry to view the PubMed entry .
PMID: # 27430727 Li, H.|Zhao, P.|Xu, Q.|Shan, S.|Hu, C.|Qiu, Z.|Xu, X.| et al. 2016. Sci Rep. 6: 29878.
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