3-[(Tetrahydro-furan-2-ylmethyl)-carbamoyl]-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
Molecular Weight:
265.31
Molecular Formula:
C14H19NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Leptomycin B is a potent and specific nuclear export inhibitor, and class II histone deacetylase inhibitor. It alkylates and inhibits CRM1 (exportin), a protein required for nuclear export of proteins containing a nuclear export sequence (NES). In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, it blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-kappaB/IkappaB, and it stabilizes the expression of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-[(Tetrahydro-furan-2-ylmethyl)-carbamoyl]-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 500 mg | sc-312107 | 500 mg | $284.00 |