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Molecular structure of 3-[(tert-Butoxycarbonyl)amino]-3-(3-thienyl)-propanoic acid
3-[(tert-Butoxycarbonyl)amino]-3-(3-thienyl)-propanoic acid
Molecular Weight:
271.33
Molecular Formula:
C12H17NO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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AG-490 also known as Tyrphostin B42 is a tyrosine kinase inhibitor of JAK2, EGFR, and Neu that belongs to the family of tyrphostins. In acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors. Additionally, AG-490 has been observed to block cytokine-induced activation of JAK2 in eosinophils and STAT3 activation in T cell lymphoma cells. Unlike other kinase inhibitors, AG-490 does not inhibit JAK1, Lck, Btk, Tyk2, Syk, Lyn, and Src. Research indicates that AG-490 inhibits IL-7 mediated proliferation. Inhibition of Jak kinase activity by AG-490 leads to lower levels of p85 phosphorylation and p-13 kinase activation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-[(tert-Butoxycarbonyl)amino]-3-(3-thienyl)-propanoic acid, 500 mg | sc-310602 | 500 mg | $399.00 | |||
3-[(tert-Butoxycarbonyl)amino]-3-(3-thienyl)-propanoic acid, 1 g | sc-310602A | 1 g | $533.00 |