2prime-O-Methyl GuanosineA Guanosine analog

2′-O-Methyl Guanosine (CAS 2140-71-8)

2′-O-Methyl Guanosine, CAS 2140-71-8 is rated 5.0 out of 5 by 1.
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Application: A Guanosine analog
CAS Number: 2140-71-8
Molecular Weight: 297.27
Molecular Formula: C11H15N5O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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2'-O-Methyl Guanosine is a Guanosine analog. Used in the preparation of nucleoside derivatives as inhibitors of RNA Polymerase (RNA-dependent RNA viral polymerase).


References

Eldrup, A.B., et al.: J. Med. Chem., 47, 2283 (2004), Shim, J., et al.: Antiviral Res., 243 (2003), Wang, M., et al.: J. Biol. Chem., 278, 9489 (2003),

Physical State :
Solid
Solubility :
Soluble in DMSO, methanol, and water (slightly).
Storage :
Store at room temperature
Melting Point :
227-231° C (dec.)
Boiling Point :
711.72° C at 760 mmHg
Density :
1.98 g/cm3
Refractive Index :
n20D 1.83 (Predicted)
Optical Activity :
α20/D -56.48°, c = 0.5 in 0.1N NaOH; α20/D -55°±2°, c = 1 in 1mol/LNaOH sol.
IC50 :
Hepatitis C virus NS5B-mediated RNA synthesis: IC50 = 1.2 µM (HBI10A cells); Hepatitis C virus NS5B RNA-dependent RNA polymerase: IC50 = 1.6 µM (Hepatitis C virus); Hepatitis C virus NS5B RNA-dependent RNA polymerase: IC50 = 3.8 µM; Hepatitis C virus NS5B RNA-dependent RNA polymerase: EC5050 = >50 µM (Hepatitis C virus)
pK Values :
pKa: 0.34 (Predicted), pKb: 9.85 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
188959
MDL Number :
MFCD00057053
Beilstein Registry :
1227554
SMILES :
CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C2NC(=NC3=O)N)CO)O

Download SDS (MSDS)

Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-220822, is provided as a white powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-25
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Rated 5 out of 5 by from Tong Tong, Z. et al. (PubMed 25116617) reported that 2'-O-Methyl nucleotide modified DNA substrates influence the cleavage efficiencies of BamHI and BglII. -SCBT Publication Review
Date published: 2015-07-14
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