2'-C-MethyladenosineAn inhibitor of HCV RNA replication

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2′-C-Methyladenosine (CAS 15397-12-3)

2′-C-Methyladenosine | CAS 15397-12-3 is rated 5.0 out of 5 by 1.

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Synonym: 2′-methyl-adenosine

Application: An inhibitor of HCV RNA replication

CAS Number: 15397-12-3

Purity: ≥98%

Molecular Weight: 281.27

Molecular Formula: C₁₁H₁₅N₅O₄

* Refer to Certificate of Analysis for lot specific data (including water content).

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2′-C-Methyladenosine has been shown to inhibit HCV RNA replication in the absence of cytotoxicity. The corresponding triphosphates were shown to be potent, competitive inhibitors of NS5B-catalyzed reactions in vitro.

Physical State :

Solid

Solubility :

Soluble in DMSO, and DMF.

Storage :

Store at 4° C

Melting Point :

>300° C (dec.)

Boiling Point :

~643.4° C at 760 mmHg (Predicted)

Density :

~1.9 g/cm³ (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

500900

SMILES :

C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C2N=CN=C3N)CO)O)O

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Certificate of Analysis

Catalog Number sc-283467 sc-283467A sc-283467B

Lot Number

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2'-C-Methyladenosine  Product Citations

See how others have used 2'-C-Methyladenosine. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

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PMID: # 27635472  D'Andrea, A. et al. 2016. Oncotarget.

PMID: # 27642141  Klepper, A. et al. 2016. Hepatology.

PMID: # 26584444  March, S. et al. 2015. Nat Protoc. 10: 2027-53.

PMID: # 26484416  Bralha, FN. et al. 2015. Oncotarget. 6: 37216-28.

Citations 1 to 4 of 4 total

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Rated 5 out of 5 by FL from Ong Ong, SP. et al. (PubMed 8218205) investigated the interaction of the adenyosylcobalamin-dependent ribonucleoside diphosphate reductase of Cornyebacterium nephridii with 2'-C-methyladenosine 5'-diphosphate (2'-MeADP) and 2'-C-methyluridine 5'-diphosphate (2'-MeUDP). 2'-MeADP is a potent competitive inhibitor of the reduction of the purine nucleotides ADP and GDP, while 2'-MeUDP competitively inhibits the reduction of the pyrimidine nucleotides UDP and CDP. 2'-MeADP is a very effective promoter of the tritium exchange reaction between [5'-3H2]adenosylcobalamin and the solvent, indicating that the exchange reaction is an integral part of the overall reduction. -SCBT Publication Review

Date published: 2015-02-20

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