You may not log in without verifying your email address.
Please check your email (including your spam email) for the Welcome message that was sent.
27-Hydroxycholesterol, an oxysterol secreted from macrophages, has been shown to be capable of passing through the blood-brain barrier and entering the circulation via the brain. This compound has been shown to be a cholesterol oxidation metabolite that causes an increase in levels of GADD 153 and caspase-12 in ARPE-19 cells in vitro. 27-Hydroxycholesterol has also been reported to increase levels of Aβ peptide production, reduce mitochondrial membrane potential, and induce nuclear factor κB (NFκB) and heme-oxygenase 1 (HO-1). Overall, 27-Hydroxycholesterol displays apoptotic properties via reactive oxygen species (ROS) generation, glutathione depletion, and inflammation. 27-Hydroxycholesterol is an activator of LXR α and LXR β.
1. Dasari, B., et al. 2010. BMC Ophthalmol. 10: 22. PMID: 20836858
2. Karuna, R., et al. 2011. Atherosclerosis. 214: 448-455. PMID: 21130455
3. Mateos, L., et al. 2011. J Alzheimers Dis. [Epub ahead of print]. PMID: 21297254
See how others have used 27-Hydroxycholesterol. Click on the entry to view the PubMed entry .
PMID: # 30563407 Liang, Z.|Chen, Y.|Wang, L.|Li, D.|Yang, X.|Ma, G.|Wang, Y.|Li, Y.|Zhao, H.|Liang, Y.|Niu, H.| et al. 2019. Cell Cycle. 18: 34-45.
PMID: # 30881285 2019. Front Mol Neurosci. 12: 14.
PMID: # 31139381 2019. Food Sci Nutr. 7: 1685-1694.
PMID: # 30180878 Du, T. et al. 2018. Breast Cancer Res. 20: 106.
PMID: # 29130512 Tian, W.|Pang, W.|Ge, Y.|He, X.|Wang, D.|Li, X.|Hou, H.|Zhou, D.|Feng, S.|Chen, Z.|Yang, Y.| et al. 2018. J. Cell. Biochem. 119: 2929-2938.
PMID: # 28503095 Raza, S.|Meyer, M.|Goodyear, C.|Hammer, KDP.|Guo, B.|Ghribi, O.| et al. 2017. Cancer Cell Int. 17: 52.
PMID: # 28257824 2017. Environ. Toxicol. Pharmacol. 51: 1-8.
PMID: # 28739487 2017. Toxicol In Vitro. 45: 10-18.
PMID: # 28167099 2017. Neurotoxicology. 59: 88-97.
PMID: # 28118975 Kylli, P. et al. 2017. J Chromatogr A. 1487: 147-152.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.