25-HydroxycholesterolAn activator of caspases and Bcl-2 expressor

25-Hydroxycholesterol (CAS 2140-46-7)

25-Hydroxycholesterol | CAS 2140-46-7 is rated 5.0 out of 5 by 2.
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Synonym: 5-Cholestene-3β,25-diol; (3β)-Cholest-5-ene-3,25-diol; Cholest-5-ene-3β,25-diol; 25-Hydroxy-5-cholestene-3β-ol
Application: An activator of caspases and Bcl-2 expressor
CAS Number: 2140-46-7
Purity: ≥98%
Molecular Weight: 402.65
Molecular Formula: C27H46O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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25-Hydroxycholesterol suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). This compound induces apoptosis through down-regulation of Bcl-2 expression and activation of caspases.


References

Nishio, E., et al., Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation. Biochem. Biophys. Res. Commun. 226, 928-934, (1996); Lim, H.K., et al., Oxysterols induce apoptosis and accumulation of cell cycle at G(2)/M phase in the human monocytic THP-1 cell line. Life Sci. 72, 1389-1399, (2003)

Physical State :
Solid
Solubility :
Soluble in chloroform
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
65094
MDL Number :
MFCD00057815
SMILES :
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C

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Certificate of Analysis

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25-Hydroxycholesterol  Product Citations

See how others have used 25-Hydroxycholesterol. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 30592645  Papatheodorou, P.|Song, S.|López-Ureña, D.|Witte, A.|Marques, F.|Ost, GS.|Schorch, B.|Chaves-Olarte, E.|Aktories, K.| et al. 2019. FASEB J. 33: 4883-4892.

PMID: # 30180878  Du, T. et al. 2018. Breast Cancer Res. 20: 106.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from good very good antibody,I got a pretty good data,Thans a lot
Date published: 2017-07-07
Rated 5 out of 5 by from Lu Lu, H. et al. (PubMed 25759117) found that rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon- in primary macrophages requires endogenous 25-hydroxycholesterol synthesis. -SCBT Publication Review
Date published: 2015-01-02
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