25-Hydroxycholesterol suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). This compound induces apoptosis through down-regulation of Bcl-2 expression and activation of caspases.
Nishio, E., et al., Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation. Biochem. Biophys. Res. Commun. 226, 928-934, (1996); Lim, H.K., et al., Oxysterols induce apoptosis and accumulation of cell cycle at G(2)/M phase in the human monocytic THP-1 cell line. Life Sci. 72, 1389-1399, (2003)
See how others have used 25-Hydroxycholesterol. Click on the entry to view the PubMed entry .
PMID: # 30592645 Papatheodorou, P.|Song, S.|López-Ureña, D.|Witte, A.|Marques, F.|Ost, GS.|Schorch, B.|Chaves-Olarte, E.|Aktories, K.| et al. 2019. FASEB J. 33: 4883-4892.
PMID: # 30180878 Du, T. et al. 2018. Breast Cancer Res. 20: 106.
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