MF: C27H46O2 MW: 402.70 An endogenous agonist for the nuclear receptor LXR..
Protein-Interacting Inhibitors, Activators & Substrates
LXR β Activators
24(S)-Hydroxycholesterol (CAS 474-73-7)
C 27H 46O 2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. *
Certificate of Analysis for lot specific data (including water content).
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24(S)-Hydroxycholesterol is an important metabolite of cholesterol in the brain. It is an endogenous agonist for the nuclear receptor LXR and displays neurotoxic effects on human neuroblastoma cells.
Soluble in ethanol (~20 mg/ml), DMSO (10 mg/ml)(requires warming to ~40°C), DMF (~2 mg/ml), and 1:2EtOH:PBS(pH=7.2) (~0.5 mg/ml).
Store at -20° C
~513.1° C at 760 mmHg (Predicted)
20 D 1.54 (Predicted)
5050 = 130 nM (human)
Nuclear receptor ROR-γ: K
i= 10 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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