24(S)-HydroxycholesterolAn endogenous agonist for the nuclear receptor LXR.

24(S)-Hydroxycholesterol (CAS 474-73-7)

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Synonym: Cerebrosterol
Application: An endogenous agonist for the nuclear receptor LXR.
CAS Number: 474-73-7
Molecular Weight: 402.70
Molecular Formula: C27H46O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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24(S)-Hydroxycholesterol is an important metabolite of cholesterol in the brain. It is an endogenous agonist for the nuclear receptor LXR and displays neurotoxic effects on human neuroblastoma cells.

Physical State :
Solid
Solubility :
Soluble in ethanol (~20 mg/ml), DMSO (10 mg/ml)(requires warming to ~40°C), DMF (~2 mg/ml), and 1:2EtOH:PBS(pH=7.2) (~0.5 mg/ml).
Storage :
Store at -20° C
Melting Point :
177-180° C
Boiling Point :
~513.1° C at 760 mmHg (Predicted)
Density :
~1.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
LXR-α: EC5050 = 130 nM (human)
Ki Data :
Nuclear receptor ROR-γ: Ki= 10 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
121948
SMILES :
C[C@H](CC[C@@H](C(C)C)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C

Download SDS (MSDS)

Certificate of Analysis

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