20alpha-Hydroxy Cholesterol CAS: 516-72-3
MF: C27H46O2
MW: 402.65
An allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein.

20α-Hydroxy Cholesterol (CAS 516-72-3)

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Alternate Names: 5-Cholestene-3β,20α-diol
Application: 20α-Hydroxy Cholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein
CAS Number: 516-72-3
Molecular Weight: 402.65
Molecular Formula: C27H46O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

20α-Hydroxy Cholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein that binds at a site distinct from the canonical cyclopamine binding site. 20α-Hydroxy Cholesterol activates Hedgehog (Hh) signaling (EC50 ~ 3μM for induction of Hh reporter gene transcription in in NIH 3T3 cells). It induces Smo accumulation in primary cilia and also exhibits osteogenic activity and activates the liver X receptor (LXR).


References

1. Higley, N A., et al., 1984. The steatotic and cytotoxic effects of cholesterol oxides in cultured L cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 22(12): 983-92. PMID: 6542547
2. Kilsdonk, E P., et al., 1995. Inhibition of cellular cholesterol efflux by 25-hydroxycholesterol. Journal of lipid research. 36(3): 505-16. PMID: 7775862
3. Cantwell, H., et al., 1998. The response of the antioxidant defense system in rat hepatocytes challenged with oxysterols is modified by Covi-ox. Cell biology and toxicology. 14(6): 401-9. PMID: 9879932

Physical State :
Solid
Solubility :
Soluble in Chloroform and Methanol
Storage :
Store at -20° C
Melting Point :
125-132° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
121935
SMILES :

Download SDS (MSDS)

Certificate of Analysis

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