20-Hydroxyecdysone CAS: 5289-74-7
MF: C27H44O7
MW: 480.64
An ecdysteroid in both plant and animal species that controls cell death.

20-Hydroxyecdysone (CAS 5289-74-7)

20-Hydroxyecdysone | CAS 5289-74-7 is rated 5.0 out of 5 by 1.
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Alternate Names: β-Ecdysone; 2β,3β,14α,20R,22R,25-Hexahydroxy-5β-cholest-7-en-6-one; Ecdysterone
Application: 20-Hydroxyecdysone is a ecdysteroid in both plant and animal species that controls cell death
CAS Number: 5289-74-7
Purity: ≥95%
Molecular Weight: 480.64
Molecular Formula: C27H44O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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20-Hydroxyecdysone is the most widely occurring ecdysteroid in both plant and animal species. It controls cell death during metamorphosis of Drosophila melanogaster.


References

H. Hampshire and D.H.S. Horn; Chem. Commun. 37 (1966) M.N. Galbraith and D.H.S. Horn; Chem. Commun. 905 (1966) H. Rimpler and G. Schulz; THL 22, 2033 (1967) L. Canonica, et al.; Phytochemistry 14, 525 (1975) Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death: C. Cao, et al.; J. Cell Biol. 176, 843 (2007

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (partly), ethanol, methanol (20 mg/ml), DMSO, and acetic acid.
Storage :
Store at -20° C
Melting Point :
242-244° C
Boiling Point :
702.06° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
Ecdysone receptor: IC50 = 45.71 nM (drosophila melanogaster); Ecdysone receptor: IC50 = 5.5 µM (lucilia cuprina)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
FZ8060000
PubChem CID :
Merck Index :
14: 3491
MDL Number :
MFCD00036740
Beilstein Registry :
1917578

Download SDS (MSDS)

Certificate of Analysis

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20-Hydroxyecdysone (CAS 5289-74-7)  Product Citations

See how others have used 20-Hydroxyecdysone (CAS 5289-74-7). Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 29778903  Wulff, JP.|Capriotti, N.|Ons, S.| et al. 2018. J. Insect Physiol. 108: 31-39.

PMID: # 26898150  Venne, P. et al. 2016. J Chromatogr A. 1438: 57-64.

PMID: # 26627129  Lee, SR. et al. 2016. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 192: 38-48.

PMID: # 27809786  Yang, B.|Huang, W.|Zhang, J.|Xu, Q.|Zhu, S.|Zhang, Q.|Beerntsen, BT.|Song, H.|Ling, E.| et al. 2016. BMC Genomics. 17: 866.

PMID: # 25979705  Fresán, U. et al. 2015. Biology open. 4: 852-7.

PMID: # 31658986  J. Exp. Med. 217:

Citations 1 to 6 of 6 total

Do you know the solubility of this in water?

Asked by: elffriend
Thank you for your question. This biochemical is soluble in water (partly), ethanol, methanol (20 mg/ml), DMSO, and acetic acid.
Answered by: Tech Service
Date published: 2019-08-20

How do you do HPLC for analyzing the purity of 20E. I want to know the details.

Asked by: Jia Qiangqiang
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot. Please call our Asian Support office toll-free at 800-820-8626, email [email protected], or contact us by live chat.
Answered by: Technical Support
Date published: 2016-10-26
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Rated 5 out of 5 by from Works fine Works fine. Going to order again soon.
Date published: 2015-09-18
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