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2-tert-Butylcyclohexanone (CAS 1728-46-7)

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Alternate Names:
2-t-Butylcyclohexanone; 2-(tert-Butyl)cyclohexanone
CAS Number:
1728-46-7
Molecular Weight:
154.25
Molecular Formula:
C10H18O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-tert-Butylcyclohexanone, a cyclic ketone with unique properties, has garnered interest among scientists and researchers. Its versatility has led to extensive studies in various fields, including organic synthesis and biochemistry. Being a volatile organic compound (VOC), 2-tert-Butylcyclohexanone exhibits reactivity with atmospheric components like oxygen and nitrogen, giving rise to a range of byproducts, including ozone and other pollutants. Moreover, microorganisms in the environment can metabolize this compound, leading to the production of other substances.


2-tert-Butylcyclohexanone (CAS 1728-46-7) References

  1. Regiochemical studies of the ring expansion reactions of hydroxy azides with cyclic ketones.  |  Smith, BT., et al. 2000. J Org Chem. 65: 3771-4. PMID: 10864763
  2. A simple and efficient copper-catalyzed procedure for the hydrosilylation of hindered and functionalized ketones.  |  Díez-González, S., et al. 2005. J Org Chem. 70: 4784-96. PMID: 15932319
  3. Nickel supported carbon nanofibers as an active and selective catalyst for the gas-phase hydrogenation of 2-tert-butylphenol.  |  Díaz, JA., et al. 2012. J Colloid Interface Sci. 380: 173-81. PMID: 22682327
  4. Promoting effect of 2-n-alkylcyclohexanones on the percutaneous absorption of indomethacin.  |  Quan, D., et al. 1989. Drug Des Deliv. 5: 149-57. PMID: 2577985
  5. Effect of cyclohexanone derivatives on percutaneous absorption of ketoprofen and indomethacin.  |  Akitoshi, Y., et al. 1988. Drug Des Deliv. 2: 239-45. PMID: 3255318
  6. RIFM fragrance ingredient safety assessment, 2-tert-butylcyclohexanone, CAS Registry Number 1728-46-7.  |  Api, AM., et al. 2021. Food Chem Toxicol. 156 Suppl 1: 112562. PMID: 34555464
  7. Influence of novel percutaneous absorption enhancers, cyclohexanone and piperidone derivatives, on histopathology of rat skin.  |  Danyi, Q., Kozo, T., Toji, M., Koichi, I., & Tsuneji, N. 1991. International journal of pharmaceutics. 68(1-3): 239-253.
  8. Electrocatalytic hydrogenation of alkyl-substituted phenols in aqueous solutions at a Raney nickel electrode in the presence of a non-micelle-forming cationic surfactant  |  Ilikti, H., Rekik, N., & Thomalla, M. 2004. Journal of applied electrochemistry. 34: 127-136.
  9. Solvent-free reduction of aldehydes and ketones using solid acid-activated sodium borohydride  |  BT Cho, SK Kang, MS Kim, SR Ryu, DK An. 2006. Tetrahedron. 62(34): 8164-8168.
  10. Stereoselective hydrogenation of tert-butylphenols over charcoal-supported rhodium catalyst in supercritical carbon dioxide solvent  |  Hiyoshi, N., Rode, C. V., Sato, O., Tetsuka, H., & Shirai, M. 2007. Journal of Catalysis. 252(1): 57-68.
  11. Baeyer–Villiger oxidation of ketones with hydrogen peroxide catalyzed by Sn–aniline complex  |  Zhang, Q. H., Wang, S. F., & Lei, Z. Q. 2007. Chinese Chemical Letters. 18(1): 4-6.
  12. Aluminum and gallium complexes as homogeneous catalysts for reduction/oxidation reactions  |  Goldsmith, C. R. 2018. Coordination Chemistry Reviews. 377: 209-224.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-tert-Butylcyclohexanone, 5 g

sc-225547
5 g
$255.00