2-TEDCCAS: 132465-10-2
MF: C16H13NO4S
MW: 315.34
A 5-LO, 12-LO, and 15-LO inhibitor.

2-TEDC (CAS 132465-10-2)

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Synonym: 2-(1-Thienyl)ethyl 3,4-dihydroxybenzylidenecyanoacetate
Application: A 5-LO, 12-LO, and 15-LO inhibitor
CAS Number: 132465-10-2
Molecular Weight: 315.34
Molecular Formula: C16H13NO4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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2-TEDC is a potent inhibitor of 5-LO (IC50 = 0.09 μM), 12-LO (IC50 = 0.013 μM), and 15-LO (IC50 = 0.5 μM) (lipoxygenases).


References

Cho et al (1991) Novel caffeic acid derivatives - extremely potent inhibitors of 12-lipoxygenase. J.Med.Chem. 34 1503.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (25 mM).
Storage :
Desiccate at 4° C
Melting Point :
207.37° C (Predicted)
Boiling Point :
~558.5° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
12-LO: IC50 = 13 nM; 5-LO: IC50 = 0.09 µM; 15-LO: IC50 = 0.5 µM
pK Values :
pKa: 8.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4324255
MDL Number :
MFCD00894731
SMILES :
C1=CSC(=C1)CCOC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N

Download SDS (MSDS)

Certificate of Analysis

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