2-phenyl-amino-N6-endo-norbornyladenineCAS: 863202-33-9
MF: C18H20N6
MW: 320.4
An A3 AR antagonist.

2-phenyl-amino-N6-endo-norbornyladenine (CAS 863202-33-9)

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Application: An A3 AR antagonist
CAS Number: 863202-33-9
Purity: ≥98%
Molecular Weight: 320.4
Molecular Formula: C18H20N6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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2-phenyl-amino-N6-endo-norbornyladenine is a potent and selective Adenosine A3-R (A3 AR) antagonist exhibiting a Ki of 37 nM with 60 and 200-fold selectivity over A1 and A2A adenosine receptors, respectively.


References

Perreira, M., Jiang, J., Klutz, A.M., et al. "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem 48 4910-4918 (2005). Chen, S., Zhang, Q., Wu, X., et al. Dedifferentiation of lineage-committed cells by a small molecule. J Am Chem Soc 126 410-411 (2004).

Formulation :
A solution in ethanol
Physical State :
Liquid
Solubility :
Soluble in water (0.2 mg/ml at 25.0° C), DMSO (~10 mg/ml), DMF (~10 mg/ml), ethanol, and DMSO:PBS(pH7.2)(1:4) (~0.2 mg/ml).
Storage :
Store at -20° C
Boiling Point :
78° C
Ki Data :
A3AR: Ki= 37 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11290174
MDL Number :
MFCD18432683
SMILES :
C1CC2CC1CC2NC3=NC(=NC4=C3NC=N4)NC5=CC=CC=C5

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Certificate of Analysis

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2-phenyl-amino-N6-endo-norbornyladenine  Product Citations

See how others have used 2-phenyl-amino-N6-endo-norbornyladenine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27510152  Liu, C.|Skaldin, M.|Wu, C.|Lu, Y.|Zavialov, AV.| et al. 2016. Sci Rep. 6: 31370.

Citations 1 to 1 of 1 total
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