2-Methylthioadenosine Triphosphate Sodium Salt is an ATP analogue, which acts as a P2Y agonist. Studies involving rat smooth muscle indicate that 2-Methylthioadenosine Triphosphate Tetrasodium Salt causes a concentration dependent relaxation. The compound displays an EC50= 240 nM in rat smooth muscle. P2Y receptors are G-coupled protein receptors, which functions as a mediator of vasorelaxtion as a result of nitric oxide production. Furthermore, 2-Methylthioadenosine Triphosphate Tetrasodium Salt and extracellular ATP can influence glomerular haemodynamics through the activation of P2 receptors located on its cell surface.
1. Jankowski, M., et al. 2001. J. Physiol. 530: 123-130. PMID: 11136864 2. Hansmann, G., et al. 1997. Naunyn Schmiedebergs Arch Pharmacol. 356: 641-652. PMID: 940204 3. Burnstock, G., et al. 1983. Br. J. Pharmacol. 79: 907-913. PMID: 6317121 4. Cusack, N.J., et al. 1982. Br. J. Pharmacol. 75: 397-400. PMID: 7186826
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HeinrichHeinrich, A. et al. (PubMed 18063000) examined the P2 receptor-mediated modulation of [3H]glutamate and [3H]noradrenaline release in rat spinal cord slices. 2-Methylthioadenosine Triphosphate (2-MeSATP, 10-300microM) increased resting and electrically evoked [3H]glutamate and [3H]noradrenaline efflux, and this effect was prevented by the P2X1 receptor selective antagonist 4,4',4'',4'''-[carbonylbis[imino-5,1,3-benzenetriyl bis (carbonyl-imino)]] tetrakis (benzene-1,3-disulfonic acid) octasodium salt (NF449, 100nM). -SCBT Publication Review
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