2-Methylthio-ADP trisodium saltA P2Y1, P2Y12 and P2Y13 agonist

2-Methylthio-ADP trisodium salt (CAS 475193-31-8)

2-Methylthio-ADP trisodium salt | CAS 475193-31-8 is rated 5.0 out of 5 by 1.
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Synonym: 2-(Methylthio)adenosine 5'-diphosphate; 2-(Methylthio)adenosine-5'-(trihydro gen diphosphate) trisodium salt; 2-Methylthio-ADP
Application: A P2Y1, P2Y12 and P2Y13 agonist
CAS Number: 475193-31-8
Purity: ≥98%
Molecular Weight: 539.24
Molecular Formula: C11H14N5O10P2S•3Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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2-Methylthio-ADP trisodium salt is a potent purinergic agonist for the receptors P2Y1, P2Y12 and P2Y13 and a platelet aggregating agent. In addition, studies show that 2-Methylthio-ADP trisodium salt functions better as a human platelet adenylate cyclase inhibitor than a platelet aggregator. Furthermore, 2-Methylthio-ADP trisodium salt is more effective at platelet aggregation and cAMP inhibition than ADP. Alternate studies show that preincubation of human vascular smooth muscle cells with thrombin amplifies the agonist effects of 2-Methylthio-ADP trisodium salt. Upon binding to P2Y12 receptors 2-Methylthio-ADP trisodium salt can increase the induction of interleukin 6 expression and cell mitogenesis. Inhibiting this pathway can be done by RNA interference-mediated knockdown and inhibition of the receptor with the selective antagonist R-138727 (sc-220298).


References

1. Cusack, N.J., et al. 1982. Br. J. Pharmacol. 77: 329-333. PMID: 7139191
2. Macfarlane, D.E., et al. 1983. J. Clin. Invest. 71: 420-428. PMID: 6298277
3. Sak, K., et al. 2002. Arch. Biochem. Biophys. 397: 131-136. PMID: 11747319
4. Zhang, F.L., et al. 2002. J. Pharmacol. Exp. Ther. 301: 705-713. PMID: 11961076

Formulation :
10 mM in water
Appearance :
Aqueous solution
Physical State :
Liquid
Solubility :
Soluble in water (50 mM).
Storage :
Store at -20° C
Refractive Index :
n20D 1.88 (Predicted)
IC50 :
P2Y12: EC5050 = 0.89 nM; P2Y1: EC5050 = 2.5 nM (human); P2Y purinoceptor 1: EC5050 = 2.5 nM (meleagris gallopavo); P2Y13: EC5050 = 19 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD00153838
SMILES :
[Na+].[Na+].[Na+].CSc1nc(N)c2ncn([C@H]3O[C@@H](COP(=O)([O-])OP(=O)([O-])[O-])[C@H](O)[C@@H]3O)c2n1

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Certificate of Analysis

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2-Methylthio-ADP trisodium salt  Product Citations

See how others have used 2-Methylthio-ADP trisodium salt. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 30460241  Tullemans, BME. et al. 2018. Front Cardiovasc Med. 5: 142.

PMID: # 31652008  Transfusion.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Amisten Amisten, S. et al. (PubMed 20526761) used 2-Methylthio-ADP to demonstrate that ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice. -SCBT Publication Review
Date published: 2015-06-11
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