2-Methylthio-ADP trisodium salt is a potent purinergic agonist for the receptors P2Y1, P2Y12 and P2Y13 and a platelet aggregating agent. In addition, studies show that 2-Methylthio-ADP trisodium salt functions better as a human platelet adenylate cyclase inhibitor than a platelet aggregator. Furthermore, 2-Methylthio-ADP trisodium salt is more effective at platelet aggregation and cAMP inhibition than ADP. Alternate studies show that preincubation of human vascular smooth muscle cells with thrombin amplifies the agonist effects of 2-Methylthio-ADP trisodium salt. Upon binding to P2Y12 receptors 2-Methylthio-ADP trisodium salt can increase the induction of interleukin 6 expression and cell mitogenesis. Inhibiting this pathway can be done by RNA interference-mediated knockdown and inhibition of the receptor with the selective antagonist R-138727 (sc-220298).
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PMID: # 30460241 Tullemans, BME. et al. 2018. Front Cardiovasc Med. 5: 142.
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