2-Hydroxymyristic acidA protein myristoylation inhibitor

2-Hydroxymyristic acid (CAS 2507-55-3)

2-Hydroxymyristic acid | CAS 2507-55-3 is rated 5.0 out of 5 by 1.
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Application: A protein myristoylation inhibitor
CAS Number: 2507-55-3
Purity: >97%
Molecular Weight: 244.4
Molecular Formula: C14H28O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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2-Hydroxymyristic acid has the capability to distinguish between myristoylation and palmitoylation, and is therefore able to inhibit protein myristoylation in cells. Many proteins require myristoylation to be fully active, and inhibition of myristoylation by 2-Hydroxymyristic acid will suppress full protein activity. Metabolic activation to the CoA thioester may be required for inhibitory potency in cells. 2-Hydroxymyristic acid is also capable of reducing the quantity of p56lck, a protein partly responsible for T cell activation, available for signal transduction at the plasma membrane through its inhibition of protein N-myristoylation.


References

1. Paige, L.A., et al. 1990. Biochemistry. 29: 10566-10573. PMID: 2271666
2. Spiegel, A.M., et al. 1991. Trends Biochem. Sci. 16: 338-341. PMID: 1949155
3. Nadler, M.J., et al. 1993. Biochemistry. 32: 9250-9255. PMID: 8103677
4. Paige, L.A., et al. 1993. J. Biol. Chem. 268: 8669-8674. PMID: 8473310
5. Harper, D.R., et al. 1993. J. Gen. Virol. 74: 1181-1184. PMID: 8389801

Physical State :
Solid
Solubility :
Soluble in water (0.35 mg/ml), ethanol (≥ 27 mg/ml), DMSO (25 mg/ml), DMF (≥ 27 mg/ml), 100% ethanol (25 mg/ml), chloroform (25 mg/ml), and 1:2 solution of ethanol: PBS(pH 7.2) (~0.35 mg/ml).
Storage :
Store at -20° C
Melting Point :
80-81° C
Boiling Point :
377.45° C at 760 mmHg (Predicted)
Density :
0.97 g/cm3 (Predicted)
Refractive Index :
n20D 1.47 (Predicted)
pK Values :
pKa: 3.86 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
1563
MDL Number :
MFCD00014342
EC Number :
219-714-0
Beilstein Registry :
1725369
SMILES :
CCCCCCCCCCCCC(O)C(O)=O

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Certificate of Analysis

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2-Hydroxymyristic acid  Product Citations

See how others have used 2-Hydroxymyristic acid. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 26041296  Rathbun, JY. et al. 2015. J. Virol. 89: 8428-43.

PMID: # 19759156  Urata, S. et al. 2009. J. Virol. 83: 12651-12655.

PMID: # 18434404  Life, RB. et al. 2008. J. Virol. 82: 6109-6119.

PMID: # 16617111  Vilas, GL. et al. 2006. Proc. Natl. Acad. Sci. U.S.A. 103: 6542-6547.

PMID: # 15452271  Perez, M. et al. 2004. J. Virol. 78: 11443-11448.

PMID: # 12805216  Saeki, K. et al. 2003. EMBO J. 22: 3015-3026.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Urata Urata, S. et al. (PubMed 19759156) used 2-Hydroxymyristic acid, an acid that is able to inhibit protein myristoylation, to test its effects on TACV Z budding. Budding of TACV Z was completely inhibited in cells treated with 2-Hydroxymyristic acid. -SCBT Publication Review
Date published: 2015-05-27
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