2-HydroxybohemineA Cdc2 and Cdk2 inhibitor

2-Hydroxybohemine (CAS 471270-60-7)

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Application: A Cdc2 and Cdk2 inhibitor
CAS Number: 471270-60-7
Purity: ≥95%
Molecular Weight: 356.42
Molecular Formula: C18H24N6O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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2-Hydroxybohemine is an inhibitor of cyclin-dependent kinase 1 (Cdc2 or CDK1, IC50 = 100nM) and cell division protein kinase 2 (CDK2, IC50 = 80nM).


References

1. Vermeulen, K., et al., 2002. Antiproliferative effect of plant cytokinin analogues with an inhibitory activity on cyclin-dependent kinases. Leukemia. 16(3): 299-305. PMID: 11896531

Physical State :
Solid
Solubility :
Soluble in DMSO (100 µM), DMF (100 µM), 100% ethanol (100 µM), acetone, and methanol.
Storage :
Store at -20° C
Melting Point :
252.39° C (Predicted)
Boiling Point :
632.73° C at 760 mmHg (Predicted)
Density :
1.35 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
Cdc2: IC50 = 100 nM; Cdk2 : IC50 = 80 nM
pK Values :
pKa: 9.84 (Predicted), 4.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4155347
MDL Number :
MFCD06411405
SMILES :
CC(C)N1C=NC2=C1N=C(N=C2NCC3=CC=CC=C3O)NCCCO

Download SDS (MSDS)

Certificate of Analysis

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