2-Hydroxy-flutamideAn inhibitor of proliferation of estradiol-induced growth of MCF-7 breast cancer cells

2-Hydroxy-flutamide (CAS 52806-53-8)

2-Hydroxy-flutamide | CAS 52806-53-8 is rated 5.0 out of 5 by 1.
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Synonym: 2-Hydroxyflutamide; Hydroxyniphtholide; Sch 16423
Application: An inhibitor of proliferation of estradiol-induced growth of MCF-7 breast cancer cells
CAS Number: 52806-53-8
Purity: ≥98%
Molecular Weight: 292.21
Molecular Formula: C11H11F3N2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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2-Hydroxy-flutamide is a metabolite of flutamide found to inhibit the proliferation of estradiol-induced growth of MCF-7 breast cancer cells. 2-Hydroxy-flutamide is an inhibitor of AR.


References

1. Di Monaco, M., et al. 1995. J. Cancer Res. Clin. Oncol. 121: 710-714. PMID: 7499441
2. Shet, M.S., et al. 1997. Drug Metab. Dispos. 25: 1298-303. PMID: 9351907

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/ml), chloroform, methanol, and ethyl acetate.
Storage :
Store at -20° C
Melting Point :
139-141° C
Boiling Point :
443.80° C at 760 mmHg (Predicted)
Density :
1.47 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
AR: IC50 = 15 nM (human); AR: IC50 = 52 nM (mouse); androgen receptor LBD T877A: EC5050 = 100 nM (mouse); PR: IC50 = 2.01 µM (human)
Ki Data :
AR: Ki= 2 nM (human); AR: Ki= 2.1 µM (rat)
pK Values :
pKa: 12.87 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TX1466250
PubChem CID :
91649
MDL Number :
MFCD00563126
SMILES :
CC(C)(C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Blobaum Blobaum, AL. et al. (PubMed 26265743) screened a compound library of clinically approved drugs and identified the androgen receptor antagonist flutamide and its pharmacologically active metabolite 2-Hydroxy-flutamide as heterotropic activators of cytochrome P450 3A in vitro and in vivo. -SCBT Publication Review
Date published: 2015-01-07
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