Date published: 2026-1-26

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2-Chloroethyl chloroformate (CAS 627-11-2)

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Alternate Names:
2-Chloroethoxycarbonyl chloride
CAS Number:
627-11-2
Molecular Weight:
142.97
Molecular Formula:
C3H4Cl2O2
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Chloroethyl chloroformate, an organochlorine compound, finds versatile utility across various domains. Its applications span the synthesis of peptides, organic compounds, pharmaceuticals, agrochemicals, and industrial products. Additionally, it plays a pivotal role in protein, DNA, and lipid synthesis. Serving as a versatile reagent, it contributes to a wide array of chemical syntheses and reactions. Its mechanism entails the formation of a covalent bond between the carbon atom of 2-Chloroethyl chloroformate and the oxygen atom of the target molecule. This covalent bond arises from the reaction between 2-Chloroethyl chloroformate and the target molecule′s oxygen atom, resulting in the generation of a fresh carbon-oxygen bond. Importantly, the reaction is reversible, and its course can be reversed by introducing water or other solvents into the system.


2-Chloroethyl chloroformate (CAS 627-11-2) References

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  5. Classical tosylate/chloride leaving group approach supports a tetrahedral transition state for additions to trigonal carbon.  |  D'Souza, MJ., et al. 2018. Trends Org Chem. 19: 1-11. PMID: 30740002
  6. Synthesis, activity and mechanism of alkoxy-, carbamato-, sulfonamido-, thioureido-, and ureido-derivatives of 2,4,5-trimethylpyridin-3-ol against inflammatory bowel disease.  |  Chaudhary, CL., et al. 2020. J Enzyme Inhib Med Chem. 35: 1-20. PMID: 31619080
  7. The Influence of a Terminal Chlorine Substituent on the Kinetics and the Mechanism of the Solvolyses of n-Alkyl Chloroformates in Hydroxylic Solvents.  |  D'Souza, MJ., et al. 2020. Int J Mol Sci. 21: PMID: 32575637
  8. Effects of glyphosate residues and different concentrate feed proportions in dairy cow rations on hepatic gene expression, liver histology and biochemical blood parameters.  |  Heymann, AK., et al. 2021. PLoS One. 16: e0246679. PMID: 33577576

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Chloroethyl chloroformate, 100 g

sc-230212
100 g
$150.00