Molecular structure of 2-Bromo-1,4-naphthoquinone, CAS Number: 2065-37-4
2-Bromo-1,4-naphthoquinone (CAS 2065-37-4)
Alternate Names:
2-bromonaphthalene-1,4-dione; 2-bromonaphthoquinone
Application:
2-Bromo-1,4-naphthoquinone is a menadione analog used for cancer research
CAS Number:
2065-37-4
Purity:
≥97%
Molecular Weight:
237.05
Molecular Formula:
C10H5BrO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Bromo-1,4-naphthoquinone is a naphthoquinone derivative and menadione analog. It has been used in cancer research studies to increase H2O2 production in tumor cell lines. The compound shows anticancer activity in tissue culture and has been found to effectively inhibit the growth of cancer cells by disrupting cellular metabolism. Its mechanism of action involves reactions with amines specifically at the C2 position of the naphthoquinone ring, resulting in the release of bromine radicals that readily react with DNA and various cellular components. In vitro studies have shown it has minimal toxicity and redox potentials similiar to those of water.
2-Bromo-1,4-naphthoquinone (CAS 2065-37-4) References
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- In Vivo Anti-inflammatory, Analgesic, and Sedative Studies of the Extract and Naphthoquinone Isolated from Diospyros kaki (Persimmon). | Bawazeer, S. and Rauf, A. 2021. ACS Omega. 6: 9852-9856. PMID: 33869965
- Synthesis of some NH- and NH,S- substituted 1,4-quinones. | Kaçmaz, A. 2021. Turk J Chem. 45: 475-484. PMID: 34104058
- Accessing Chemo- and Regioselective Benzylic and Aromatic Oxidations by Protein Engineering of an Unspecific Peroxygenase. | Knorrscheidt, A., et al. 2021. ACS Catal. 11: 7327-7338. PMID: 34631225
- Naphthoquinone as a New Chemical Scaffold for Leishmanicidal Inhibitors of Leishmania GSK-3. | Sebastián-Pérez, V., et al. 2022. Biomedicines. 10: PMID: 35625873
- Novel one-pot synthesis of a library of 2-aryloxy-1,4-naphthoquinone derivatives. Determination of antifungal and antibacterial activity. | Chaves-Carballo, K., et al. 2022. RSC Adv. 12: 18507-18523. PMID: 35799928
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Bromo-1,4-naphthoquinone, 10 g | sc-225182 | 10 g | $90.00 |