2-Aminopurine DihydrochlorideA protein kinase inhibitor that can alter cell cycle checkpoints

2-Aminopurine Dihydrochloride (CAS 76124-64-6)

2-Aminopurine Dihydrochloride | CAS 76124-64-6 is rated 5.0 out of 5 by 1.
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Synonym: 9H-Purin-2-amine Dihydrochloride; Isoadenine Dihydrochloride
Application: A protein kinase inhibitor that can alter cell cycle checkpoints
CAS Number: 76124-64-6
Purity: 98%
Molecular Weight: 208.05
Molecular Formula: C5H5N52HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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2-Aminopurine Dihydrochloride is a purine analog that acts as a protein kinase inhibitor. The compound is a mutagen that can incorporate into DNA and has been used as a fluorescent probe. Studies indicate that it can alter checkpoints in the phases of the cell cycle, in particular alter cells to enter mitosis in S-phase arrested cells incorrectly and override a γ radiation induced G2 block. Additionally, it has been demonstrated that 2-Aminopurine Dihydrochloride inhibits PITSLREβ1 protein kinase activity, and that it can alter the structure and dynamics of DNA. 2-Aminopurine Dihydrochloride does not effect the protein kinase activity of p34cdc2. 2-Aminopurine Dihydrochloride is an inhibitor of PKR.


References

1. Johnson, H.G., et al. 1966. Proc. Natl. Acad. Sci. U.S.A. 55: 1453-1456. PMID: 5336284
2. Rogan, E.G. and Bessman, M.J. 1970. J. Bacteriol. 103: 622-633. PMID: 4919986
3. Andreassen, P.R., et al. 1992. Proc. Natl. Acad. Sci. U.S.A. 89: 2272-2276. PMID: 1549593
4. Xiang, J., et al. 1994. Biochem. Biophys. Res. Commun. 199: 1167-1173. PMID: 8147857
5. Reha-Krantz, L.J. 2009. Methods Mol. Biol. 521: 381-396. PMID: 19563118
6. Dallmann, A., et al. 2010. Angew. Chem. Int. Ed. Engl. 49: 5989-5992. PMID: 20632340

Physical State :
Solid
Solubility :
Soluble in water (~10 mg/ml with agitation) at 50° C, and DMSO (~10 mg/ml with agitation) at 50° C.
Storage :
Desiccate at -20° C
Melting Point :
>260° C (dec.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UO7475000
PubChem CID :
53411880
MDL Number :
MFCD00005566
EC Number :
207-197-4
SMILES :
C1=C2C(=NC(=N1)N)N=CN2.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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2-Aminopurine Dihydrochloride  Product Citations

See how others have used 2-Aminopurine Dihydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 20018207  Yamana, Y. et al. 2010. Plasmid. 63: 119-127.

PMID: # 19717610  Sarnacki, SH. et al. 2009. J. Bacteriol. 191: 6694-6700.

PMID: # 17150189  Furset, G. et al. 2007. Biochem. Biophys. Res. Commun. 352: 642-649.

PMID: # 15854645  Sioud, M. et al. 2005. J. Mol. Biol. 348: 1079-1090.

PMID: # 15153468  Karikó, K. et al. 2004. J. Immunol. 172: 6545-6549.

PMID: # 12562818  Matic, I. et al. 2003. J. Bacteriol. 185: 1459-1461.

PMID: # 12802279  Huang, S. et al. 2003. Oncogene. 22: 3721-33.

Citations 1 to 7 of 7 total
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Rated 5 out of 5 by from Huang et al Huang et al. (PubMed ID 12802279) found that 2-Aminopurine Dihydrochloride, a protein kinase inhibitor, suppressed p53 phosphorylation in response to various forms of DNA damage. -SCBT Publication Review
Date published: 2015-03-26
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