Date published: 2026-4-24

1-800-457-3801

SCBT Portrait Logo
Seach Input

2-Amino-6,8-dihydroxypurine Hydrochloride (CAS 1246818-54-1)

0.0(0)
Write a reviewAsk a question

Alternate Names:
8-Hydroxyguanine Hydrochloride
Application:
2-Amino-6,8-dihydroxypurine Hydrochloride is a diagnostic product of nucleic acid oxidative damage
CAS Number:
1246818-54-1
Purity:
≥90%
Molecular Weight:
203.59
Molecular Formula:
C5H5N5O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

2-Amino-6,8-dihydroxypurine hydrochloride functions as a purine analog that can be used to study its effects on cellular processes. It can act as a competitive inhibitor of adenosine deaminase, an enzyme involved in purine metabolism, thereby affecting the levels of adenosine and other purine nucleosides in cells. 2-Amino-6,8-Dihydroxypurine Hydrochloride can also interfere with the synthesis of nucleic acids by inhibiting enzymes such as ribonucleotide reductase and DNA polymerase. 2-Amino-6,8-dihydroxypurine hydrochloride may induce DNA damage and inhibit cell proliferation by interfering with DNA replication and repair processes. Its mechanism of action involves disrupting purine metabolism and nucleic acid synthesis, which may be useful for investigating the molecular mechanisms underlying these cellular processes.


2-Amino-6,8-dihydroxypurine Hydrochloride (CAS 1246818-54-1) References

  1. Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column.  |  Park, EM., et al. 1992. Proc Natl Acad Sci U S A. 89: 3375-9. PMID: 1565629
  2. DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells.  |  Spencer, JP., et al. 1995. FEBS Lett. 374: 233-6. PMID: 7589542
  3. Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer.  |  Jaruga, P., et al. 1994. FEBS Lett. 341: 59-64. PMID: 8137923
  4. DNA damage by peroxynitrite characterized with DNA repair enzymes.  |  Epe, B., et al. 1996. Nucleic Acids Res. 24: 4105-10. PMID: 8932358
  5. Oxidative decay of DNA.  |  Beckman, KB. and Ames, BN. 1997. J Biol Chem. 272: 19633-6. PMID: 9289489

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Amino-6,8-dihydroxypurine Hydrochloride, 10 mg

sc-202438
10 mg
$49.00

2-Amino-6,8-dihydroxypurine Hydrochloride, 25 mg

sc-202438A
25 mg
$116.00