2-[5-(7-{3-[Ethyl-(2-hydroxy-ethyl)-amino]-propoxy}-quinazolin-4-ylamino)-2H-pyrazol-3-yl]-N-(3-fluoro-phenyl)-acetamideA highly selective ARK-2 inhibitor

2-[5-(7-{3-[Ethyl-(2-hydroxy-ethyl)-amino]-propoxy}-quinazolin-4-ylamino)-2H-pyrazol-3-yl]-N-(3-fluoro-phenyl)-acetamide (CAS 722544-51-6)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 89ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: Barasertib
Application: A highly selective ARK-2 inhibitor
CAS Number: 722544-51-6
Purity: ≥98%
Molecular Weight: 507.56
Molecular Formula: C26H30FN7O3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

2-[5-(7-{3-[Ethyl-(2-hydroxy-ethyl)-amino]-propoxy}-quinazolin-4-ylamino)-2H-pyrazol-3-yl]-N-(3-fluoro-phenyl)-acetamide is a highly selective ARK-2 inhibitor with IC50 of 0.37 nM.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (102 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (3 mg/ml at 25° C).
Storage :
Store at -20° C
Boiling Point :
~796.7° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
ARK-2: IC50 = 1 nM (human); ARK-1: IC50 = 1.4 µM (human); HERG: IC50 > 30 µM (human)
Ki Data :
ARK-2: Ki= 0.36 nM; ARK-3: Ki= 17 nM (human); SW-620: Ki= 17 nM (human); KHS: Ki= 19.95 nM (human); ARK-1: Ki= 1369 nM
pK Values :
pKa: 13.07 (Predicted), pKb: 8.46 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16007391
MDL Number :
MFCD10687152
SMILES :
CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. AZD1152-HQPA, sc-265334, is a yellow solid.
Answered by: Chemical Support 4
Date published: 2017-06-23
  • y_2019, m_11, d_17, h_20CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.2
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_265334, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 206ms
  • QUESTIONS, PRODUCT
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 93ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.