2,3-DCPEA compound that induces both upregulation and S-phase arrest in p21

2,3-DCPE (CAS 1009555-55-8)

2,3-DCPE | CAS 1009555-55-8 is rated 5.0 out of 5 by 1.
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Synonym: 2-[[3-(2,3-dichlorophenoxy)propyl]amino]-ethanol, monohydrochloride
Application: A compound that induces both upregulation and S-phase arrest in p21
CAS Number: 1009555-55-8
Purity: ≥98%
Molecular Weight: 300.6
Molecular Formula: C11H15Cl2NO2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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2,3 DCPE displays anticancer agent properties and induces ERK activation. Causes apoptosis in many tumor cell lines and is known to specifically cleave caspase-8, caspase-3, caspase-9, and poly(ADP-ribose) polymerase in cancer cells, but not in human fibroblasts. Shown to reduce the protein level of Bcl-XL. Triggered cell death in OAW42-R ovarian carcinoma cells with inhibition of Bcl-2 expression and increased cytotoxic effect of cisplatin in OAW42-R resistant cells. 2,3-DCPE reported to induce S-phase arrest and upregulate p21.


References

1. Wu, S., et al. 2004. Cancer Res. 64: 1110-1113. PMID: 14871845
2. Zhu, H., et al. 2004. Oncogene 23: 4984-4992. PMID: 15122344

Physical State :
Solid
Solubility :
Soluble in water (>25 mg/ml), ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), and PBS (pH7.2) (~10 mg/ml).
Storage :
Store at -20° C
IC50 :
LoVo colon cancer cell line: IC50 = 0.89 µM (human); normal fibroblasts: IC50 = 12.6 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
52913859
SMILES :
C1=CC(=C(C(=C1)Cl)Cl)OCCCNCCO.Cl

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2,3-DCPE  Product Citations

See how others have used 2,3-DCPE. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 17276501  Villedieu, M. et al. 2007. Gynecol. Oncol. 105: 373-384.

PMID: # 15122344  Zhu, H. et al. 2004. Oncogene. 23: 4984-4992.

PMID: # 15334064  Zhu, N. et al. 2004. Oncogene. 23: 7545-7551.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Zhu et al Zhu et al. (PubMed ID 15122344) foudn that 2,3-DCPE suppressed the proliferation of Bcl-XL-overexpressing cancer cells without inducing apoptosis by activating S-phase arrest and p21 expression in human colon cancer cells. -SCBT Publication Review
Date published: 2015-01-26
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