2-(1,8-naphthyridin-2-yl)-PhenolSelectively enhances STAT1 transcription activity

2-(1,8-naphthyridin-2-yl)-Phenol (CAS 65182-56-1)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 55ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application: Selectively enhances STAT1 transcription activity
CAS Number: 65182-56-1
Purity: ≥98%
Molecular Weight: 222.24
Molecular Formula: C14H10N2O
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

2-(1,8-naphthyridin-2-yl)-Phenol is a cell-permeable naphthyridinyl-phenolic compound which selectively enhances cytokine-induced STAT1 transcription activity, but not STAT3 or NF-κB transcription activity. 2-(1,8-naphthyridin-2-yl)-Phenol is shown to prolong INF-g-induced tyrosine phosphorylation of STAT1 in NIH3T3 cells and accentuate the STAT1-dependent growth inhibition in MCF-7 and 2fTGH cancer cells.


1. Lynch, Rebecca A., et al., 2007. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer research. 67(3): 1254-61. PMID: 17283162

Physical State :
Solubility :
Soluble in DMSO (≥10 mg/ml).
Storage :
Store at 4° C
Melting Point :
193-196° C
Boiling Point :
408.07° C at 760 mmHg (Predicted)
Density :
1.28 g/cm3 (Predicted)
Refractive Index :
n20D 1.70
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 55ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 5ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.