2-(1,8-naphthyridin-2-yl)-Phenol is a cell-permeable naphthyridinyl-phenolic compound which selectively enhances cytokine-induced STAT1 transcription activity, but not STAT3 or NF-κB transcription activity. 2-(1,8-naphthyridin-2-yl)-Phenol is shown to prolong INF-g-induced tyrosine phosphorylation of STAT1 in NIH3T3 cells and accentuate the STAT1-dependent growth inhibition in MCF-7 and 2fTGH cancer cells.
1. Lynch, Rebecca A., et al., 2007. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer research. 67(3): 1254-61. PMID: 17283162
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