2-(1,8-naphthyridin-2-yl)-PhenolSelectively enhances STAT1 transcription activity

2-(1,8-naphthyridin-2-yl)-Phenol (CAS 65182-56-1)

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Application: Selectively enhances STAT1 transcription activity
CAS Number: 65182-56-1
Purity: ≥98%
Molecular Weight: 222.24
Molecular Formula: C14H10N2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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2-(1,8-naphthyridin-2-yl)-Phenol is a cell-permeable naphthyridinyl-phenolic compound which selectively enhances cytokine-induced STAT1 transcription activity, but not STAT3 or NF-κB transcription activity. 2-(1,8-naphthyridin-2-yl)-Phenol is shown to prolong INF-g-induced tyrosine phosphorylation of STAT1 in NIH3T3 cells and accentuate the STAT1-dependent growth inhibition in MCF-7 and 2fTGH cancer cells.


References

1. Lynch, Rebecca A., et al., 2007. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer research. 67(3): 1254-61. PMID: 17283162

Physical State :
Solid
Solubility :
Soluble in DMSO (≥10 mg/ml).
Storage :
Store at 4° C
Melting Point :
193-196° C
Boiling Point :
408.07° C at 760 mmHg (Predicted)
Density :
1.28 g/cm3 (Predicted)
Refractive Index :
n20D 1.70
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6789423
MDL Number :
MFCD00203050
SMILES :
C1=CC(=C2C=CC3=C(N2)N=CC=C3)C(=O)C=C1

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Certificate of Analysis

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