1α,25-Dihydroxyvitamin D3Also known as Calcitriol, the active form of vitamin D3, and an activator of PKC and VDR

1α,25-Dihydroxyvitamin D3 (CAS 32222-06-3)

1α,25-Dihydroxyvitamin D3 | CAS 32222-06-3 is rated 5.0 out of 5 by 1.
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Synonym: Calcitriol; 1α,25-Dihydroxycholecalciferol
Application: Also known as Calcitriol, the active form of vitamin D3, and an activator of PKC and VDR
CAS Number: 32222-06-3
Purity: ≥97%
Molecular Weight: 416.64
Molecular Formula: C27H44O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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1α,25-Dihydroxyvitamin D3 (Calcitriol) is a metabolite of the secosteroid vitamin D3. This hormone stimulates intestinal calcium transport at a much higher rate than vitamin D3 and hydroxy D3, and is considered to represent the biologically active form of vitamin D3. In addition to regulating the movement of calcium in the blood and bone, 1α,25-Dihydroxyvitamin D3 participates in developmental regulation and signaling. It stimulates an increase in protein kinase C levels with an effect on the regulation of c-myc transcription and activation of Raf kinase. 1α,25-Dihydroxyvitamin D3 is shown to increase the synthesis of prostacyclin with a correlated increase in cyclooxygenase activity, indicating a further role in vascular regulation. 1α,25-Dihydroxyvitamin D3 (Calcitriol) is an activator of PKC and VDR.


References

1. Mangelsdorf, D.J., et al. 1984. J. Cell Biol. 98: 391-398. PMID: 6319426
2. Carthy, E.P., et al. 1989. Hypertension. 13: 954-959. PMID: 2786849
3. Simpson, R.U., et al. 1989. J. Biol. Chem. 264: 19710-19715. PMID: 2684961
4. Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166: 916-923. PMID: 2405860
5. Wakasugi, M., et al. 1991. Prostaglandins. 42: 127-136. PMID: 1775635
6. Lissoos, T.W., et al. 1993. J. Biol. Chem. 268: 25132-25138. PMID: 8227076
7. de Boland, A.R., et al. 1994. J. Biol. Chem. 269: 8675-8679. PMID: 8132595
8. Morrison, N.A., et al. 1994. Nature. 367: 284-287. PMID: 8161378
9. Slater, S.J., et al. 1995. J. Biol. Chem. 270: 6639-6643. PMID: 7896803

Physical State :
Solid
Solubility :
Soluble in ethanol (83 mg/ml at 25° C), DMSO (83 mg/ml at 25° C), methanol, and chloroform.
Storage :
Store at -20° C
Boiling Point :
~565.0° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
Optical Activity :
α22/D +48° in methanol
IC50 :
HCT-116: IC50 = 0.01 nM (human); PBMC: IC50 = 0.03 nM (human); VDR: IC50 = 0.7 nM (human); T47D: IC50 = 1.3 nM (human); RWLeu4: IC50 = 6 nM (human)
Ki Data :
Vitamin D receptor: Ki= 0.03 nM (Gallus gallus); Vitamin D receptor: Ki= 0.05 nM (rat); HL-60: Ki= 2 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
FZ4645000
PubChem CID :
5280453
Merck Index :
14: 1644
MDL Number :
MFCD00867079
EC Number :
250-963-8
Beilstein Registry :
7559394
SMILES :
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](C[C@@H](C3=C)O)O)C

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1α,25-Dihydroxyvitamin D3  Product Citations

See how others have used 1α,25-Dihydroxyvitamin D3. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 18 total

PMID: # 31013259  Lee, JJ.|Liu, X.|O'Neill, D.|Beggs, MR.|Weissgerber, P.|Flockerzi, V.|Chen, XZ.|Dimke, H.|Alexander, RT.| et al. 2019. JCI Insight. 5:

PMID: # 29072505  Pastorková, B. et al. 2017. Drug Chem Toxicol. 41: 1-7.

PMID: # 26817629  Swami, S. et al. 2016. Endocrine-related cancer. 23: 251-64.

PMID: # 27098343  Wegler, C. et al. 2016. Basic & clinical pharmacology & toxicology.

PMID: # 27534550  Machacek, C. et al. 2016. J. Immunol. 197: 2229-38.

PMID: # 27327272  Bartonkova, I. et al. 2016. Chem. Res. Toxicol.

PMID: # 26510996  Kosters, A. et al. 2016. Hepatol. Res. 46: 794-803.

PMID: # 26774453  Capelo, R. et al. 2016. Biochem. Pharmacol. 103: 74-84.

PMID: # 23455988  Nissou, MF. et al. 2013. J. Alzheimers Dis. 35: 553-64.

PMID: # 15312241  Kondo, T. et al. 2004. J. Bone Miner. Res. 19: 1411-1419.

Citations 1 to 10 of 18 total

Hi. I would like to know if you can give a small sample to test the labeling. Thanks.

Asked by: Ellen Conceicao
Thank you for your question. The smallest size we can offer of this chemical, 1α,25-Dihydroxyvitamin D3, is a 50 µg size for $197.00 (catalog number: sc-202877B).
Answered by: Technical Support
Date published: 2017-05-09
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Rated 5 out of 5 by from Sun Sun, X. et al. (PubMed 15231722) used 1 ,25-Dihydroxyvitamin D3 (Calcitriol) to determine its role in stimulating adipose tissue apoptosis in aP2 transgenic mice. They found that increasing dietary calcium suppressed 1 ,25-Dihydroxyvitamin D3 and increased the rate of adipose apoptosis. -SCBT Publication Review
Date published: 2015-03-19
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