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(+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid (CAS 61696-54-6)

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Alternate Names:
(2R,3R,11R,12R)-1,4,7,10,13,16-Hexaoxacyclooctadecane-2,3,11,12-tetracarboxylic Acid
Application:
(+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid is a chiral crown ether used in capillary liquid chromatography
CAS Number:
61696-54-6
Molecular Weight:
440.35
Molecular Formula:
C16H24O14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(18-Crown-6)-2,3,11,12-tetracarboxylic Acid is a compound that functions as a complexing agent in various chemical reactions. Its mechanism of action involves forming stable complexes with metal cations, particularly potassium, which can be utilized in the synthesis of coordination polymers and supramolecular assemblies. The compound′s ability to chelate metal ions allows for the selective extraction and separation of specific metal ions from mixtures, making it a useful in analytical chemistry and environmental remediation studies. (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid has been employed in the development of ion-selective electrodes and sensors for detecting metal ions in solution. Its complexation properties play a role in facilitating the transport of metal ions across membranes, contributing to the advancement of ion transport studies and membrane technology. The compound′s function as a complexing agent enables its application in various experimental applications, particularly in the fields of coordination chemistry, materials science, and analytical chemistry.


(+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid (CAS 61696-54-6) References

  1. Preparation and application of HPLC chiral stationary phases based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid.  |  Hyun, MH. 2006. J Sep Sci. 29: 750-61. PMID: 16830487
  2. Preparation and application of a new doubly tethered chiral stationary phase containing N-CH3 amide linkage based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid.  |  Hyun, MH., et al. 2007. Chirality. 19: 74-81. PMID: 17089339
  3. Chiral NMR discrimination of piperidines and piperazines using (18-crown-6)-2,3,11,12-tetracarboxylic acid.  |  Lovely, AE. and Wenzel, TJ. 2006. J Org Chem. 71: 9178-82. PMID: 17109544
  4. Stereoisomeric separation of pharmaceutical compounds using CE with a chiral crown ether.  |  Zhou, L., et al. 2007. Electrophoresis. 28: 2658-66. PMID: 17657760
  5. HPLC enantioseparation of beta2-homoamino acids using crown ether-based chiral stationary phase.  |  Berkecz, R., et al. 2009. J Sep Sci. 32: 981-7. PMID: 19306252
  6. Preparation of a new crown ether-based chiral stationary phase containing thioester linkage for the liquid chromatographic separation of enantiomers.  |  Cho, HS., et al. 2009. J Chromatogr A. 1216: 7446-9. PMID: 19406408
  7. High-performance liquid chromatographic enantioseparation of beta(2)-amino acids using a long-tethered (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid-based chiral stationary phase.  |  Ilisz, I., et al. 2010. J Chromatogr A. 1217: 1075-82. PMID: 19616782
  8. Liquid chromatographic direct resolution of flecainide and its analogs on a chiral stationary phase based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid.  |  Lee, A., et al. 2010. Chirality. 22: 693-8. PMID: 20014243
  9. Enantioseparation of alpha-amino acids on an 18-crown-6-tetracarboxylic acid-bonded silica by capillary electrochromatography.  |  Lee, T., et al. 2010. J Chromatogr A. 1217: 1425-8. PMID: 20060534
  10. Heart-cutting 2D-CE with on-line preconcentration for the chiral analysis of native amino acids.  |  Anouti, S., et al. 2010. Electrophoresis. 31: 1029-35. PMID: 20309913
  11. High-performance liquid chromatographic enantioseparation of unusual isoxazoline-fused 2-aminocyclopentanecarboxylic acids on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid-based chiral stationary phases.  |  Sipos, L., et al. 2012. Chirality. 24: 817-24. PMID: 22847684
  12. Development of HPLC Chiral Stationary Phases Based on (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid and Their Applications.  |  Hyun, MH. 2015. Chirality. 27: 576-88. PMID: 26237013
  13. Utilization of (18-crown-6)-2,3,11,12-tetracarboxylic acid as a chiral NMR solvating agent for diamines and β-amino acids.  |  Rodriguez, YC., et al. 2015. Chirality. 27: 708-15. PMID: 26285042
  14. Liquid chromatographic resolution of proline and pipecolic acid derivatives on chiral stationary phases based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid.  |  Cho, ES., et al. 2018. J Sep Sci. 41: 1192-1198. PMID: 29044998
  15. Resolution of methoxyphenamine and its analogues on a chiral stationary phase based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid.  |  Jeon, H. and Hyun, MH. 2018. J Sep Sci. 41: 4281-4285. PMID: 30267460

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid, 10 mg

sc-208881A
10 mg
$229.00

(+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid, 25 mg

sc-208881
25 mg
$332.00

(+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid, 50 mg

sc-208881B
50 mg
$601.00