17-PA CAS: 694438-95-4
MF: C25H34O
MW: 350.54
An antagonist of neurosteroid GABA potentiation.

17-PA (CAS 694438-95-4)

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Application: 17-PA is an antagonist of neurosteroid GABA potentiation
CAS Number: 694438-95-4
Molecular Weight: 350.54
Molecular Formula: C25H34O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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17-PA is a steroid analog that demonstrates selective antagonism of neurosteroid potentiation of GABA responses. 17-PA is demonstrated to antagonize both the response augmentation and the direct gating of GABA receptors by 5α-reduced potentiating steroids. This effect of 17-PA was shown to be selective for 5α-reduced potentiating steroids, as 5β-reduced potentiators were only weakly affected.


References

1. Mennerick, S., et al. 2004. Mol.Pharmacol. 65: 1191-1197. PMID: 15102947
2. Akk, G., et al. 2007. Mol Pharmacol. 71: 461-472. PMID: 17105870

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mM), and ethanol (50 mM).
Storage :
Store at room temperature
Boiling Point :
472.94° C at 760 mmHg (Predicted)
Density :
1.07 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD09971119

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Certificate of Analysis

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