17-ODYA (17-Octadecynoic acid)A potent suicide inhibitor of LTB4 ω-oxidase

17-ODYA (17-Octadecynoic acid) (CAS 34450-18-5)

17-ODYA (17-Octadecynoic acid) | CAS 34450-18-5 is rated 5.0 out of 5 by 1.
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Application: A potent suicide inhibitor of LTB4 ω-oxidase
CAS Number: 34450-18-5
Purity: ≥98%
Molecular Weight: 280.45
Molecular Formula: C18H32O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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17-ODYA (17-Octadecynoic acid) is a potent suicide inhibitor of CYP4F3 (leukotriene B4 (LTB4) ω-oxidase) (IC50<5 μM), LTB 20-hydroxylase and renal CYP450 omega-hydroxylase. It is a potent and selective inhibitor of CYP4A11 (fatty acid ω-hydroxylase) (IC50<100 nM) and has shown to irreversibly inhibit CYP2J2 (cytochrome P450 epoxygenases). Blocks biosynthesis of 20-HETE and at a concentration of 10 μM, 17-ODYA completely inhibits the bradykinin-dependent transport of sodium chloride in rat TALH cells.


References

1. Shak, S., et al. 1985. J. Biol. Chem. 260: 13023-13028. PMID: 2997155
2. Zou, A.P., et al. 1994. J. Pharmacol. Exp. Ther. 268: 474-481. PMID: 8301590
3. Dong, H., et al. 1997. Br. J. Pharmacol. 120: 695-701. PMID: 9051310
4. Grider, J.S., et al. 1997. Can. J. Physiol. Pharmacol. 75: 91-96. PMID: 9114929
5. Sun, C.W., et al. 1998. Circ. Res. 83: 1069-1079. PMID: 9831701
6. Uddin, M.R., et al. 1998. Hypertension. 3: 242-247. PMID: 9453310

Physical State :
Solid
Solubility :
Soluble in ethanol (25 mg/ml) and DMSO (25 mg/ml)
Storage :
Store at -20° C
Melting Point :
62-65
Boiling Point :
~400.8° C at 760 mmHg (Predicted)
Density :
~0.9 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
1449
MDL Number :
MFCD00077382
SMILES :
C#CCCCCCCCCCCCCCCCC(=O)O

Download SDS (MSDS)

Certificate of Analysis

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17-ODYA (17-Octadecynoic acid)  Product Citations

See how others have used 17-ODYA (17-Octadecynoic acid). Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 28436281  Uehara, S. et al. 2017. Xenobiotica. 1-6.

PMID: # 26673139  Galindo-Villegas, J. et al. 2016. J. Immunol. 196: 738-49.

PMID: # 26316537  Lin, YH. et al. 2015. J. Biol. Chem. 290: 25766-81.

PMID: # 17638876  Jiang, JG. et al. 2007. Cancer Res. 67: 6665-6674.

PMID: # 12468797  Zhang, C. et al. 2002. Stroke. 33: 2957-2964.

PMID: # 12069931  Alonso-Galicia, M. et al. 2002. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283: R60-R68.

PMID: # 9931140  Ito, O. et al. 1999. Hypertension. 33: 419-423.

Citations 1 to 7 of 7 total
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Rated 5 out of 5 by from Jiang et al Jiang et al. (PubMed ID 17638876) found that the epoxygenase,17-ODYA (17-Octadecynoic acid), inhibited human cancer cell migration, invasion, and adhesion and reduced EET production. -SCBT Publication Review
Date published: 2015-07-16
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