15(S)-HETrECAS: 92693-02-2
MF: C20H34O3
MW: 322.48
A 5-LO (5-lipoxygenase) inhibitor.

15(S)-HETrE (CAS 92693-02-2)

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Synonym: (8Z,11Z,13E,15S)-15-hydroxyicosa-8,11,13-trienoic acid
Application: A 5-LO (5-lipoxygenase) inhibitor
CAS Number: 92693-02-2
Molecular Weight: 322.48
Molecular Formula: C20H34O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of DGLA. It is an inhibitor of 5-LO in human PMNL with an IC50 value of 4.6 μM. In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE (sc-200966).


References

1 Petrich, K., Ludwig, P., Kühn, H., et al. The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leukocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: Structure-activity relationship and mechanism of action. Biochem J 314 911-916 (1996). 2 Haviv, F., Ratajczyk, J.D., DeNet, R.W., et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. J Med Chem 30 254-263 (1987).

Formulation :
A solution in ethanol
Physical State :
Liquid
Solubility :
Soluble in DMSO (~50 mg/ml), DMF (~50 mg/ml), ethanol, PBS PH 7.2 (~1 mg/ml), and water (0.8 mg/ml at 25.0° C).
Storage :
Store at -20° C
Boiling Point :
78° C
Refractive Index :
n20D 1.50 (Predicted)
IC50 :
5-LO: IC50 = 4.6 µM (human PMNL )
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5283145
MDL Number :
MFCD00084835
SMILES :
CCCCC[[email protected]@H](/C=C/C=C\\C/C=C\\CCCCCCC(=O)O)O

Download SDS (MSDS)

Certificate of Analysis

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