15(S)-HETE-biotin is a major arachidonic acid metabolite produced by the 15-LO (15-lipoxygenase) pathway and is characterized as a potent inhibitor of 5-LO. The mechanism by which 15(S)-HETE acts as a leukotriene inhibitor is not clear. In studies with P-18 mast/basophil cells, it was shown that specific 15-HETE receptors, rather than esterification, appeared to be involved in signal transduction. 15(S)-HETE-biotin can be used to detect 15(S)-HETE binding proteins and/or receptors.
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