15(S)-HETE-biotinMF: C30H48N4O4S
MW: 560.8
An inhibitor of 5-LO (5-lipoxygenase).

15(S)-HETE-biotin

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Application: An inhibitor of 5-LO (5-lipoxygenase)
Molecular Weight: 560.8
Molecular Formula: C30H48N4O4S
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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15(S)-HETE-biotin is a major arachidonic acid metabolite produced by the 15-LO (15-lipoxygenase) pathway and is characterized as a potent inhibitor of 5-LO. The mechanism by which 15(S)-HETE acts as a leukotriene inhibitor is not clear. In studies with P-18 mast/basophil cells, it was shown that specific 15-HETE receptors, rather than esterification, appeared to be involved in signal transduction. 15(S)-HETE-biotin can be used to detect 15(S)-HETE binding proteins and/or receptors.


References

1 Kang, L., Vanderhoek, J.Y. Characterization of specific subcellular 15-hydroxyeicosatetraenoic acid (15-HETE) binding sites on rat basophilic leukemia cells. Biochim Biophys Acta 1256 297-304 (1995). 2 Vanderhoek, J.Y., Bryant, R.W., Bailey, J.M. Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid. J Biol Chem 255 10064-10065 (1980). 3 Vonakis, B.M., Vanderhoek, J.Y. 15-Hydroxyeicosatetraenoic acid (15-HETE) receptors. J Biol Chem 267 23625-23631 (1992). 4 Kang, L., Vanderhoek, J.Y. Synthesis and use of a novel biotinylated probe for the chemiluminescent detection of proteins that bind 15-hydroxyeicosatetraenoic acid. Anal Biochem 250 119-122 (1997).

Formulation :
A solution in ethanol
Physical State :
Liquid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 1170, Class 3, Packing group II
PubChem CID :
71312161
SMILES :
O=C(CCCCC1SCC(N2[H] ) C1N([H] ) C2=O) N([H] ) N([H] ) C(CCC/C=C\C/C=C\C/C=C\C=C\[[email protected]@H] (O) CCCCC) =O

Download SDS (MSDS)

Certificate of Analysis

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