15(R),19(R)-hydroxy Prostaglandin E2Acts as an agonist of EP2 receptors - used for deconvoluting EP-receptor function

15(R),19(R)-hydroxy Prostaglandin E2 (CAS 54142-29-9)

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Synonym: 15(R),19(R)-hydroxy PGE2
Application: Acts as an agonist of EP2 receptors - used for deconvoluting EP-receptor function
CAS Number: 54142-29-9
Molecular Weight: 368.5
Molecular Formula: C20H32O6
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15(R),19(R)-hydroxy Prostaglandin E2 is the inverse or "unnatural" isomer at C-15 of 19(R)-Hydroxy-prostaglandin E2 (sc-201252). These 19-hydroxylated prostaglandins have been associated with selectively agonizing EP2 receptors, contrary to PGE2 (sc-201225), which can activate a variety of prostanoid receptor types. The ability of these 19-hydroxylated prostaglandins to selectively agonize EP2 receptors is useful in the deconvolution of EP-receptor function.


References

1. Cooper, I. and Kelly, R.W. 1975. Prostaglandins. 10: 507-514. PMID: 1197784
2. Woodward, D.F., et al. 1993. Prostaglandins. 46: 371-383. PMID: 8248550
3. Halm, D.R., et al. 2001. Am. J. Physiol. Gastrointest. Liver Physiol. 281: G984-G996. PMID: 11557519
4. Wise, H. 2006. Eur. J. Pharmacol. 535: 69-77. PMID: 16545798

Formulation :
A solution in ethanol
Appearance :
A solution in ethanol
Physical State :
Liquid
Storage :
Store at -20° C
Boiling Point :
78° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
O[C@H] (CCC[C@@H] (C) O) CC[C@H] 1C(O) CC(=O) C1C/C=C\\CCCC(=O) O

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