12(S)-HPETEA fatty acid and an activator of human blood leukocyte 5-LO

12(S)-HPETE (CAS 71774-10-2)

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Synonym: 12S- hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid
Application: A fatty acid and an activator of human blood leukocyte 5-LO
CAS Number: 71774-10-2
Purity: ≥98%
Molecular Weight: 336.5
Molecular Formula: C20H32O4
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* Refer to Certificate of Analysis for lot specific data (including water content).
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12(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4, and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and is a potent and selective inhibitor of CaMKII (Ca2+/calmodulin-dependent protein kinase II) from rat brain cortex. Also inhibits TXA Synthase (thromboxane synthase) and platelet aggregation via activation of GCS (guanylate cyclase). 12(S)-HPETE is an activator of VR1.


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Formulation :
50 µg/ml in ethanol
Physical State :
Solubility :
Soluble in water (0.8 mg/ml at 25.0° C), DMSO, DMF, ethanol, pH 7.2 PBS (0.8 mg/ml), 0.1M Na2CO3 (2 mg/ml), and dimethyl formamide.
Storage :
Store at -80° C
Boiling Point :
78° C
Refractive Index :
n20D 1.51
IC50 :
Ca2+-calmodulin-dependent protein kinase II: IC50 = 0.7 µM
Ki Data :
Endogenous TRPV1: Ki= 0.35 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :

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Certificate of Analysis

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