10Z-Hymenialdisine CAS: 82005-12-7
MF: C11H10BrN5O2
MW: 324.13
An ATP competitive, CK1 and GSK-3β inhibitor.

10Z-Hymenialdisine (CAS 82005-12-7)

10Z-Hymenialdisine | CAS 82005-12-7 is rated 5.0 out of 5 by 1.
  • y_2021, m_7, d_26, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.18
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_360987, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 120ms
  • REVIEWS, PRODUCT
loading
5
1
4
0
3
0
2
0
1
0
Alternate Names: 4Z)-4-(2-Amino-5-oxo-3,5-dihydro-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one
Application: 10Z-Hymenialdisine is an ATP competitive, CK1 and GSK-3β inhibitor
CAS Number: 82005-12-7
Purity: ≥97%
Molecular Weight: 324.13
Molecular Formula: C11H10BrN5O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
loading

10Z-Hymenialdisine is a novel alkaloid isolated from Axinella damicornis. It is known to act as an ATP-competitive kinase inhibitor. It exhibits inhibitory activity against cyclin-dependent kinases, CK1 and GSK-3β. It has also been shown to block the phospho 10Z-Hymenialdisine is an inhibitor of Cdk1, Cdk2, Cdk3, Cdk5, cyclin A, cyclin B, cyclin E, MEK-1 and p35. 10Z-Hymenialdisine is an inhibitor of MARK.


References

1. Supriyono, A., et al. 1995. Z. Naturforsch., C, J. Biosci. 50: 669-674. PMID: 8579685
2. Breton, J.J., et al. 1997. J. Pharmacol. Exp. Ther. 282: 459-466. PMID: 9223588
3. Roshak, A., et al. 1997. J. Pharmacol. Exp. Ther. 283: 955-961. PMID: 9353419
4. Meijer, L., et al. 2000. Chem. Biol. 7: 51-63. PMID: 10662688

Appearance :
Oil
Physical State :
Solid
Derived From :
Axinella carteri
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at -20° C
Melting Point :
273.54° C (Predicted)
Boiling Point :
630.45° C (Predicted)
Density :
~2.2 g/mL (Predicted)
Refractive Index :
n20D 1.91 (Predicted)
IC50 :
ERK2: IC50 = 6 nM (human); MEK-1: IC50 = 6 nM (human); GSK-3β: IC50 = 10 nM (human); Cyclin-dependent kinase 1/cyclin B: IC50 = 22 nM (human); Cyclin-dependent kinase 5/CDK5 activator 1: IC50 = 28 nM (human)
pK Values :
pKa: 13.96 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UY8427710
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
MDL Number :
MFCD04037007
SMILES :
C\1CNC(=O)C2=C(/C1=C/3\C(=O)N=C(N3)N)C=C(N2)Br

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 123ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Meijer et al Meijer et al. (PubMed ID 10662688) found 10Z-Hymenialdisine inhibited cyclin-dependent kinases, GSK-3beta and CK1 activation by ATP. -SCBT Publication Review
Date published: 2015-02-02
  • y_2021, m_7, d_26, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.18
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_360987, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT