1-Naphthylacetyl SpermineCAS: 122306-11-0
MF: C22H34N4O
MW: 370.53
A potent Spermidine uptake inhibitor.

1-Naphthylacetyl Spermine (CAS 122306-11-0)

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Synonym: 1-naphthylacetylspermine
Application: A potent Spermidine uptake inhibitor
CAS Number: 122306-11-0
Purity: ≥96%
Molecular Weight: 370.53
Molecular Formula: C22H34N4O
* Refer to Certificate of Analysis for lot specific data (including water content).
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1-Naphthylacetyl Spermine is a poliamine amide. It is a potent Spermidine uptake inhibitor. 1-Naphthylacetyl Spermine acts as a selective antagonist of GluR (Ca2+-permeable AMPA receptors) and protects huppocampal neurons against global ischemia-induced cell death. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.


References

Li, Y., et al.: Cancer Res., 57, 234 (1997), Muller, T., et al.: Science, 256, 1563 (1992), Hironaka, K., et al.: J. Biol. Chem., 275, 16167 (2000),

Physical State :
Solid
Storage :
Desiccate at 4° C
Melting Point :
260-262° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
129695
SMILES :
C1=CC=C2C(=C1)C=CC=C2CC(=O)NCCCNCCCCNCCCN

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1-Naphthylacetyl Spermine  Product Citations

See how others have used 1-Naphthylacetyl Spermine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26537662  Lalanne, T. et al. 2016. J. Physiol. (Lond.). 594: 837-61.

Citations 1 to 1 of 1 total
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