1-Naphthohydroxamic AcidA potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6

1-Naphthohydroxamic Acid (CAS 6953-61-3)

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Synonym: N-Hydroxynaphthalene-1-carboxamide; a-Naphthohydroxamic acid
Application: A potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6
CAS Number: 6953-61-3
Molecular Weight: 187.19
Molecular Formula: C11H9NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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1-Naphthohydroxamic Acid is a selective and potent HDAC8 inhibitor with a measured IC50 equivalent to 14 μM. 1-Naphthohydroxamic Acid also displays a IC50 >100 μM for class I HDAC1 and class II HDAC6. In contrast to pan-HDAC inhibitors, the compound does not reduce total intracellular HDAC activity.


References

1. Krennhrubec, Keris., Marshall, Brett L., Hedglin, Mark., Verdin, Eric., Ulrich, Scott M., 2007. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorganic & medicinal chemistry letters. 17(10): 2874-8. PMID: 17346959

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mg/mL), and methanol (almost transparency).
Storage :
Store at 4° C
Melting Point :
161.31 °C (Predicted)
Boiling Point :
417.22 °C (Predicted)
Density :
1.29 g/cm3
Refractive Index :
n20D 1.68
IC50 :
Plasmodium falciparum M17 Leucine Aminopeptidase: IC50 = 9.08 µM; HDAC8: IC50 = 14 µM; Arachidonate 5-lipoxygenase: IC50 = 42.66 µM (rat); MMP-3: IC50 = 50 µM (human); HDAC6: IC50 = > 100 µM
pK Values :
pKa: 8.91 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
QJ1894500
PubChem CID :
23382
MDL Number :
MFCD00059546
Beilstein Registry :
2094470
SMILES :
C1=CC=C2C(=C1)C=CC=C2C(=O)NO

Download SDS (MSDS)

Certificate of Analysis

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