1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride CAS: 23007-85-4
MF: C12H16ClN
MW: 209.71

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride (CAS 23007-85-4)

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride | CAS 23007-85-4 is rated 5.0 out of 5 by 2.
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Alternate Names: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride is also known as MPTP hydrochloride.
Application: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride is a Dopaminergic neurotoxin precursor of MPP+, widely used in research to study Parkinson′s
CAS Number: 23007-85-4
Purity: ≥98%
Molecular Weight: 209.71
Molecular Formula: C12H16ClN
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data (including water content).
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride is a dopaminergic neurotoxin that causes permanent symptoms of Parkinson′s disease by killing certain neurons in the substantia nigra of the brain. For this reason, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride can be useful in the study of Parkinson′s disease. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride is also known as MPTP hydrochloride, and Dopaminergic neurotoxin.


References

1. Burns, R.S. et al. Proc. Natl. Acad. Sci. USA. 80, 4546, (1983)

2. Langston, J.W. et al. Science, 219, 979, (1983)

3. Mogi, M. et al. Neurosci. Lett. 250, 25, (1998)

4. Przedborski, S. Jackson-Lewis, V. Mov. Disord. 13, 35, (1998)
5. Mitochondrial complex I deficiency in Parkinson′s disease; A. H. V. Schapira, J. M. Cooper, D. Dexter, J. B. Clark, P. Jenner, C. D. Marsden, J. Neurochem. 1990, 54, 823.
6. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease; G. T. Liberatore, V. Jackson-Lewis, S. Vukosavic, A. S. Mandir, M. Vila, W. G. McAuliffe, V. L. Dawson, T. M. Dawson, S. Przedborski, Nat. Med. 1999, 5, 1403.
7. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease; D. C. Wu, V. Jackson-Lewis, M. Vila, K. Tieu, P. Teismann, C. Vadseth, D.-K. Choi, H. Ischiropoulos, S. Przedborski, J. Neurosci. 2002, 22, 1763.
8. Experimental models of Parkinson′s disease (a review); M. F. Beal, Nat. Rev. Neurosci. 2001, 2, 325.
9. Animal models of Parkinson′s disease: a source of novel treatments and clues to the cause of the disease (a review); S. Duty1, P. Jenner, Br. J. Pharmacol. 2011, 164, 1357.
10. Gabriel, T. L., et al. 1999. Nature Med.5, 1403.
11. Zhang, X., et al. 2010. J. Proteome Res. 9, 1496.

Appearance :
Crystalline or powder
Physical State :
Solid
Solubility :
Soluble in DMSO and Water
Storage :
Store at -20° C
Melting Point :
254-257° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Transport :
Not available for sale outside of the United States.
PubChem CID :
SMILES :
Cl.CN1CCC(=CC1)C1=CC=CC=C1

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Certificate of Analysis

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride (CAS 23007-85-4)  Product Citations

See how others have used 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride (CAS 23007-85-4). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 33745227  Niu, M.|Zhao, F.|Bondelid, K.|Siedlak, SL.|Torres, S.|Fujioka, H.|Wang, W.|Liu, J.|Zhu, X.| et al. 2021. Aging Cell. e13347.

PMID: # 31073303  Palasz, E.|Niewiadomski, W.|Gasiorowska, A.|Mietelska-Porowska, A.|Niewiadomska, G.| et al. 2019. Neural Plast. 2019: 8215017.

PMID: # 29311899  Winner, BM.|Zhang, H.|Farthing, MM.|Karchalla, LM.|Lookingland, KJ.|Goudreau, JL.| et al. 2017. Front Aging Neurosci. 9: 410.

PMID: # 26111725  Ferguson, SA. et al. 2015. Behavioural brain research. 292: 68-78.

PMID: # 24989117  De Luca, MA. et al. 2014. J. Neurochem. 131: 284-9.

PMID: # 25064079  Sarkar, S. et al. 2014. Neurotoxicology. 44: 250-62.

PMID: # 32142862  Neuroscience. 433: 53-71.

PMID: # 33345721  Nutr Neurosci. 1-18.

PMID: # 32619030  Eur. J. Neurosci.

PMID: # 33435331  Int J Mol Sci.

Citations 1 to 10 of 10 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-206178, is provided as a white crystal. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-02-14
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Rated 5 out of 5 by from Used this chemical in mouse cells and worked well Used this chemical in mouse cells and worked well.
Date published: 2015-09-24
Rated 5 out of 5 by from Monti et al Monti et al. (PubMed ID 25698928) used the mitochondria toxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride (MPTP) known to inhibit complex 1, to induce a Parkinson-like syndrome in vivo. -SCBT Publication Review
Date published: 2015-05-14
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