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1-Ethyl-2-pyrrolidone (CAS 2687-91-4)

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Alternate Names:
NEP
CAS Number:
2687-91-4
Purity:
≥99%
Molecular Weight:
113.16
Molecular Formula:
C6H11NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-Ethyl-2-pyrrolidinone (NEP) is an artificial liquid characterized by its colorless and odorless nature, finding extensive utilization across diverse industrial sectors. Functioning as a polar aprotic solvent, 1-Ethyl-2-pyrrolidone exhibits a broad solubility spectrum, contributing to its prominence in the production of cosmetics and other goods. Its significance extends to laboratory research, where it serves as a solvent for organic synthesis and a reagent for organic reactions. 1-Ethyl-2-pyrrolidinone serves as a versatile solvent with numerous laboratory research applications. Its utility encompasses functioning as a solvent for organic synthesis, a reagent for organic reactions, and a medium for cell culture. Moreover, it contributes to the production of polymers, catalysts, and various materials. Notably, 1-Ethyl-2-pyrrolidinone finds extensive use in the extraction and purification of proteins, nucleic acids, and other biomolecules. Being a polar aprotic solvent, 1-Ethyl-2-pyrrolidinone possesses the unique ability to dissolve both polar and non-polar molecules, making it suitable for a diverse array of organic reactions. It can effectively dissolve organic reactants and products alike. Additionally, its broad range of solubility for organic molecules renders it invaluable for the extraction and purification of proteins, nucleic acids, and other biomolecules.


1-Ethyl-2-pyrrolidone (CAS 2687-91-4) References

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  2. Estimation of drug-polymer miscibility and solubility in amorphous solid dispersions using experimentally determined interaction parameters.  |  Marsac, PJ., et al. 2009. Pharm Res. 26: 139-51. PMID: 18779927
  3. [Monograph for N-Methyl-pyrrolidone (NMP) and human biomonitoring values for the metabolites 5-Hydroxy-NMP and 2-Hydroxy-N-methylsuccinimide].  |  ,. 2015. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 58: 1175-91. PMID: 26324095
  4. Large cosolutes, small cosolutes, and dihydrofolate reductase activity.  |  Acosta, LC., et al. 2017. Protein Sci. 26: 2417-2425. PMID: 28971539
  5. A mechanistic study of the effects of the 1-alkyl-2-pyrrolidones on bilayer permeability of stratum corneum lipid liposomes: a comparison with hairless mouse skin studies.  |  Yoneto, K., et al. 1995. J Pharm Sci. 84: 853-61. PMID: 7562437
  6. Effect of permeation enhancers on the release of ketoprofen through transdermal drug delivery systems.  |  Singh, SK., et al. 1996. Pharmazie. 51: 741-4. PMID: 8941942
  7. Influence of the permeation enhancers 1-alkyl-2-pyrrolidones on permeant partitioning into the stratum corneum.  |  Yoneto, K., et al. 1998. J Pharm Sci. 87: 209-14. PMID: 9519155
  8. Ultraviolet Absorption Spectra of Peptides. III. N,N-Dialkylamides Including Polyvinylpyrrolidone1  |  Leo J. Saidel. 1955,. J. Am. Chem. Soc. 77, 14,: 3892–3895.
  9. Thermal properties and hydrogen bonding in polymer blend of polybenzoxazine/poly(N-vinyl-2-pyrrolidone)  |  Yi-Che Su a, Shiao-Wei Kuo a, Ding-Ru Yei a, Hongyao Xu a b, Feng-Chih Chang a. April 2003,. Polymer. Volume 44, Issue 8,: Pages 2187-2191.
  10. Effect of Pretreatment with Ultraviolet Radiation on the Physicomechanical Properties of Photocured Coir (Cocos nucifera) Fiber with 1-Ethyl-2-Pyrrolidone (1-E-2-P) Monomer  |  Mubarak A. Khan,S. K. Bhattacharia,M. M. Ahmed &R. R. Asim. 2006 -. Polymer-Plastics Technology and Engineering. Volume 45, Issue 4: 2006 -.
  11. Fabrication of Perovskite Films with Long Carrier Lifetime for Efficient Perovskite Solar Cells from Low-Toxicity 1-Ethyl-2-Pyrrolidone  |  Lili Zhi, Yanqing Li, Xiaobing Cao, Yahui Li, Xian Cui, Daming Zhuang, Lijie Ci*, and Jinquan Wei*. 2019,. ACS Appl. Energy Mater. 2, 1,: 320–327.
  12. Preparation of planar CH3NH3PbI3 thin films with controlled size using 1-ethyl-2-pyrrolidone as solvent  |  Qiuyan Hao a, Yixia Chu a, Xuerong Zheng b, Zhenya Liu a, Liming Liang a, Jiakun Qi c, Xin Zhang a, Gang Liu d, Hui Liu a, Hongjian Chen a, Caichi Liu a. 25 June 2016,. Journal of Alloys and Compounds. Volume 671,: Pages 11-16.
  13. Effect of penetration enhancers (pyrrolidone derivatives) on multilamellar liposomes of stratum corneum lipid: a study by UV spectroscopy and differential scanning calorimetry  |  Chong-Kook Kim a, Myo-Sook Hong a, Yang-Bae Kim a, Seok-Kyu Han b. 30 June 1993,. International Journal of Pharmaceutics. Volume 95, Issues 1–3,: Pages 43-50.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-Ethyl-2-pyrrolidone, 5 g

sc-237538
5 g
$24.00

1-Ethyl-2-pyrrolidone, 100 g

sc-237538A
100 g
$137.00