1-EBIO is the first activator of epithelial KCa channels identified. 1-EBIO stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic valve endothelial cells. 1-EBIO is an activator of CFTR, SK and Ik1.
1. Devor, D.C., et al. 1996. Am. J. Physiol. 271: L775-L784. PMID: 8944721 2. Adeagbo, A.S. 1999. Eur. J. Pharmacol. 379: 151-159. PMID: 10497901 3. Kusama, N., et al. 2005. Br. J. Pharmacol. 146: 487-497. PMID: 16056232
Soluble in ethanol (100 mM), DMSO (100 mM), and tris buffer solution (33 mM).
Store at room temperature
327.75° C (Predicted)
1.16 g/cm3 (Predicted)
n20D 1.57 (Predicted)
Single ptotein: Ki= >50 µM (rat)
pKa: 12.29 (Predicted), pKb: 0.51 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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