1-β-D-Arabinofuranosylcytosine, a cytosine analogue, inhibits DNA polymerases α, δ, and ε, and RNA polymerases resulting in suppression of DNA synthesis and repair. 1-β-D-Arabinofuranosylcytosine acts as an antimetabolic agent which is responsible for damaging DNA during the S-phase of the cell cycle. In addition, 1-β-D-Arabinofuranosylcytosine inhibits nucleotide reductase enzymes that are needed for DNA synthesis to occur. Alternate studies suggest that 1-β-D-Arabinofuranosylcytosine is clastogenic to both spermatogonial cells and bone marrow. Furthermore, 1-β-D-Arabinofuranosylcytosine can be used to control the proliferation of glial cells.
1. Furth, J.J. and Cohen, S.S. 1968. Cancer Res. 28: 2061-2067. PMID: 5754840 2. Kligerman, A.D., et al. 1999. Mutat. Res. 444: 151-158. PMID: 10477349 3. Palo, A.K., et al. 2009. Mutat. Res. 673: 29-36. PMID: 19095079
Soluble in water (1:10), DMSO (1 mg/mL) at 25° C, ethanol ( <1 mg/mL) at 25° C, chloroform (1g in 1L chloroform), and methanol (1g in 300 ml methanol ).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Download SDS (MSDS)
Certificate of Analysis
Adobe Acrobat Reader is required to reliably view, print and comment on PDF documents
bvseo_sdk, java_sdk, bvseo-3.2.0
CLOUD, getContent, 130ms
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
An increase in cleaved caspaseAn increase in cleaved caspase-8 was observed by WB when comparing untreated Jurkat cells with those that have been treated with 1- -D-Arabino furanosylcytosine. -SCBT QC
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.