1-β-D-ArabinofuranosylcytosineA cystosine analog and a potent inhibitor of replicative DNA synthesis

1-β-D-Arabinofuranosylcytosine (CAS 147-94-4)

1-β-D-Arabinofuranosylcytosine | CAS 147-94-4 is rated 5.0 out of 5 by 1.
  • y_2019, m_9, d_16, h_7
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201628, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 85ms
  • REVIEWS, PRODUCT
Synonym: Cytosine 1-β-D-arabinofuranoside; Arabinosylcytosine
Application: A cystosine analog and a potent inhibitor of replicative DNA synthesis
CAS Number: 147-94-4
Purity: ≥98%
Molecular Weight: 243.2
Molecular Formula: C9H13N3O5
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

1-β-D-Arabinofuranosylcytosine, a cytosine analogue, inhibits DNA polymerases α, δ, and ε, and RNA polymerases resulting in suppression of DNA synthesis and repair. 1-β-D-Arabinofuranosylcytosine acts as an antimetabolic agent which is responsible for damaging DNA during the S-phase of the cell cycle. In addition, 1-β-D-Arabinofuranosylcytosine inhibits nucleotide reductase enzymes that are needed for DNA synthesis to occur. Alternate studies suggest that 1-β-D-Arabinofuranosylcytosine is clastogenic to both spermatogonial cells and bone marrow. Furthermore, 1-β-D-Arabinofuranosylcytosine can be used to control the proliferation of glial cells.


References

1. Furth, J.J. and Cohen, S.S. 1968. Cancer Res. 28: 2061-2067. PMID: 5754840
2. Kligerman, A.D., et al. 1999. Mutat. Res. 444: 151-158. PMID: 10477349
3. Palo, A.K., et al. 2009. Mutat. Res. 673: 29-36. PMID: 19095079

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (1:10), DMSO (1 mg/mL) at 25° C, ethanol ( <1 mg/mL) at 25° C, chloroform (1g in 1L chloroform), and methanol (1g in 300 ml methanol ).
Storage :
Store at 4° C
Melting Point :
215-217° C
Boiling Point :
545.68° C at 760 mmHg (Predicted)
Density :
1.89 g/cm3 (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
Optical Activity :
α20/D +158°, c = 1 in water
IC50 :
HL-60: IC50 = 119.24 nM (human); DNA synthesis: IC50 = 16 nM (wild-type CCRF-CEM cells); MOLT-4: IC50 = 230.26 nM (human); CCRF-CEM: IC50 = 267.27 nM (human); CCRF-HSB-2: IC50 = 35.36 nM (human)
Ki Data :
CDD: Ki= 190 µM (human)
pK Values :
pKa: 13.48 (Predicted), pKb: 4.26 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
HA5425000
PubChem CID :
114682
Merck Index :
14: 2784
MDL Number :
MFCD00066487
EC Number :
205-705-9
Beilstein Registry :
89175
SMILES :
NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@H](O)C1O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 130ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from An increase in cleaved caspase An increase in cleaved caspase-8 was observed by WB when comparing untreated Jurkat cells with those that have been treated with 1- -D-Arabino furanosylcytosine. -SCBT QC
Date published: 2015-03-22
  • y_2019, m_9, d_16, h_7
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201628, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 39ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.