1,5-Isoquinolinediol is a small molecule with cell protective and neuroprotective properties. 1,5-isopuinolinediol is an inhibitor of both PARP-1 (poly (ADP-ribose) polymerase-1) and NOS2 (inducible nitric oxide synthase). PARP and NOS2 activations are implicated in deleterious inflammatory responses and suppression of their activity by 1,5 isoquinolinediol has been correlated to cellular protection and survival. The DNA excision-repair enzyme PARP (poly (ADP-ribose) synthetase, PARS) is activated by free radical oxidative cleavage of the DNA backbone, and excessive PARS activation leads to deplation of cellular NAD and ATP, progressing to cell death. A study demonstrates taht 1,5-isoquinolinediol protects against the neurotoxicity generated by NO-induced PARS activation and by NMDA in rat brain neurons. The Inhibition of PARP by 1,5-isoquinolinediol has also been correlated to a decrease in illegitimate recombination in gene targeting techniques, increasing the efficiency of specific alterations to chromosomal DNA.
1. Banasik, M., et al. 1992. J. Biol. Chem. 267: 1569-1575. PMID: 1530940
2. Zhang, J., et al. 1994. Science. 263: 687-689. PMID: 8080500
3. Dalmau, M., et al. 1996. Exp. Cell Res. 228: 14-18. PMID: 8892965
4. Semionov, A., et al. 2003. Biochem. Cell Biol. 81: 17-24. PMID: 12683632
5. Olszanecki, R., et al. 2006. J. Physiol. Pharmacol. 57: 109-117. PMID: 16601319
See how others have used 1,5-Isoquinolinediol. Click on the entry to view the PubMed entry .
PMID: # 28576564 Pant, R. et al. 2017. Neurosci. Lett. 653: 208-214.
PMID: # 24347828 Mohammad, G. et al. 2013. Mediators of inflammation. 2013: 510451.
PMID: # 18082271 Kujundzić, RN. et al. 2008. Immunol. Lett. 115: 153-159.
PMID: # 12897160 Leppard, JB. et al. 2003. Mol. Cell. Biol. 23: 5919-5927.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.