1,4-Benzoquinone is a major metabolite of benzene. It has been found to generate H2O2 in cells. It has been suggested that the peroxide reacts with Cu(I) to produce an active species that induces internucleosomal DNA fragmentation.
1. Takeuchi, R., et al. 1990. FEBS Lett. 261: 63-66. PMID: 2307236 2. Hiraku, Y., et al. 1996. Cancer Res. 56: 5172-5178. PMID: 8912853 3. Lin, B., et al. 2007. J. Pharmacol. Exp. Ther. 322: 59-69. PMID: 17468299
Soluble in water (10 g/L) at 25° C, ethanol, ether, alkaline solutions, methanol, Benzene, acetone, and Ethyl acetate.
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ChowChow, PW. et al. (PubMed 25645895) investigated the mechanism linking benzene exposure to targeting hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) using phenotypic and clonogenic analyses. Mouse bone marrow (BM) cells were exposed ex vivo to the benzene metabolite, 1,4-benzoquinone (1,4-BQ), for 24h. 1,4-BQ caused lineage-related cytotoxicity in mouse HPCs, demonstrating greater toxicity in single-lineage progenitors than in those of multi-lineage. -SCBT Publication Review
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